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HA-100 (hydrochloride)

HA-100 (hydrochloride) ??? ???

?? ??:: 210297-47-5

???:: HA-100 (hydrochloride)

???(??):: 5-(1-Piperazinylsulfonyl)-isoquinoline 2HCl;HA-100 dihydrochloride DISCONTINUED, Offer I891000;5-piperazin-1-ylsulfonylisoquinoline:dihydrochloride;Isoquinoline, 5-(1-piperazinylsulfonyl)-, hydrochloride (1:2)

CBNumber:: CB53152624

???:: C13H16ClN3O2S

??? ??:: 313.8

MOL ??:: 210297-47-5.mol

?? ?? 16

HA-100 (hydrochloride) ??

?? ??: Store at -20°C

???: insoluble in EtOH; ≥131.8 mg/mL in H2O; ≥19.17 mg/mL in DMSO with ultrasonic

??? ??: ??? ??

?? ? ?? ??
?? ? ???? ?? (GHS)

????(GHS):

?? ?:

Warning

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	P- ??
H302	??? ???	?? ?? ?? - ??	?? 4	??	P264, P270, P301+P312, P330, P501
H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??	P264, P280, P305+P351+P338,P337+P313P
H335	?? ???? ??? ? ??	?? ???? ?? - 1? ??;???? ??	?? 3	??

??????:

P261	??·?·??·???·??·...·????? ??? ????.
P264	?? ??? ?? ??? ????.
P264	?? ??? ?? ??? ????.
P270	? ??? ??? ??? ???, ???? ???? ???.
P271	?? ?? ??? ? ?? ???? ?????.
P280	????/???/???/?????? ?????.
P301+P312	??? ???? ??? ????(??)? ??? ????.
P302+P352	??? ??? ??? ?? ????.
P304+P340	???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P321	(…) ??? ???.
P330	?? ?????.
P332+P313	?? ??? ??? ???? ??· ??? ????.
P337+P313	?? ?? ??? ???? ???? ??· ??? ????.
P403+P233	??? ??? ? ?? ?? ??? ???? ?????.
P405	???? ?????.
P501	...? ??? / ??? ?? ???.

NFPA 704

	0
2		0

HA-100 (hydrochloride) C??? ??, ??, ??

??

HA-100 is an isoquinoline compound with an added piperazinylsulfonyl group that acts as an inhibitor of protein kinases (PKs), including PKA, PKC, and PKG (IC₅₀s = 8, 12, and 4 μM, respectively). It less effectively blocks the activity of myosin light chain kinase (IC₅₀ = 240 μM).

??

HA-100 dihydrochloride is an inhibitor of MYLK, PKA, and PKC.

HA-100 (hydrochloride) ?? ?? ? ???

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HA-100 (hydrochloride) ?? ??

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???	??	???	??	?? ?	??
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