??? ????? ????
|
|
??? ????? ???? ??
- ???
- 145-146 °C(lit.)
- ??
- 1.371 g/cm3
- ?? ??
- 2-8°C
- ???
- >1000g/L(20°C)
- ??? ??
- ??? ??
- ?? ?? (pKa)
- pK1:7.66(＋1) (25°C)
- ??
- ???
- ??
- ?? ??
- ??????(pH)
- 2.9 (10g/l, H2O, 20℃)
- ???
- >1000G/L(20℃)
- ??
- Hygroscopic
- BRN
- 3594034
- InChIKey
- TXTWXQXDMWILOF-UHFFFAOYSA-N
- CAS ??????
- 623-33-6(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 41-36/37/38 | ||
| ????? | 26-39-24/25-37/39 | ||
| WGK ?? | 3 | ||
| RTECS ?? | MC0525000 | ||
| TSCA | Yes | ||
| HS ?? | 29224995 | ||
| ???? ?? | KE-18056 |
??? ????? ???? C??? ??, ??, ??
??? ??
Crystalline??
As a Glycine (G615990) ester, Glycine ethyl ester hydrochloride can be used as parakeratosis inhibitor and external composition for skin.Synthesis
A production method for glycine ethyl ester hydrochloride:First add dehydrated ethanol in 1# reactor, pass into anhydrous hydrogen chloride to obtain hydrochloric acid-ethanol solution; Add a certain amount of triethyl orthoformate and glycine and hydrochloric acid-ethanol solution in 2# reactor, in the Reaction under action; after the reaction is complete, distill and recover ethanol and ethyl formate; then add alcohol-ether mixture, wash, filter, concentrate, recrystallize, and vacuum dry to obtain ethyl glycine hydrochloride.Purification Methods
Crystallise it from absolute EtOH or EtOH/Et2O. [Marvel Org Synth Coll Vol II 310 1943, Beilstein 4 II 780, 4 III 3 75.]??? ????? ???? ?? ?? ? ???
???
?? ??
1-(Boc-???)???????????
N-Boc-3-cyano-4-hydroxypyrrolidine
ethyl 2-(3-bromo-2-oxopyrazin-1(2H)-yl)acetate
??2-[(2-???????)???]?????
2,2-Dimethyl-3-(2-methylpropyl)cyclopropanecarboxylic acid p-(methoxymethyl)benzyl ester
tert-??3-(?????)-4-????????-1-???????
Ethyl N-(diphenylmethylene)glycinate
Ethyl imidazole-4-carboxylate
ethyl 2-(3,4-dihydro-2,3-dioxopyrazin-1(2H)-yl)acetate
N-(ETHOXYCARBONYL)-N-(ETHOXYCARBONYKLETHYL)?????????
H-GLY-AMC HBR
1-Aminocyclopropanecarboxylic acid
Glycine methyl ester hydrochloride
N-FORMYLGLYCINE ETHYL ESTER
3-BROMO-6-METHYL-2-OXO-1(2H)-?????????????
Anagrelide
ethyl 2-(3,4-dihydro-6-methyl-2,3-dioxopyrazin-1(2H)-yl)acetate
Ethyl diazoacetate
4-?????????????
??????
4-BOC-AMINOMETHYL-1-N-BOC-PYRROLIDIN-3-OL
4,5,6,7-TETRAHYDRO-2-METHYLFURO[2,3-C]PYRIDINE
??? ????? ???? ?? ??
???( 783)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
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??? ????? ???? ?? ??:
?????-?? ??? ????? ????? ???? ?? 5,5-???-2-?????-3-??????? ?? ????????? D-4-????????? ?????? ??? ???????? ????????? ????? ???? ?? ???? ??? ????? ????
L-Arginine ethyl ester dihydrochloride
Topotecan hydrochloride
Glycine methyl ester hydrochloride
Ethyl L-phenylalaninate hydrochloride
Ethyl nipecotate
4-Aminophenylacetic acid