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(E)-??1-???-3-(???(??)???)-2-?????-6-???????

(E)-??1-???-3-(???(??)???)-2-?????-6-???????
(E)-??1-???-3-(???(??)???)-2-?????-6-??????? ??? ???
?? ??:
1168152-07-5
???:
(E)-??1-???-3-(???(??)???)-2-?????-6-???????
???(??):
(E)-??1-???-3-(???(??)???)-2-?????-6-???????
???:
(E)-Methyl 1-acetyl-3-(Methoxy(phenyl)Methylene)-2-oxoindoline-6-carboxylate
???(??):
Intedanib Impurity 34;Nintedanib Impurity 149;Intedanib(Nintedanib) Impurity 18;(Z)-methyl 1-acetyl-3-(ethoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate;(E)-Methyl 1-acetyl-3-(Methoxy(phenyl)Methylene)-2-oxoindoline-6-carboxylate;Methyl (E)-1-Acetyl-3-[methoxy(phenyl)methylene]-2-oxoindoline-6-carboxylate;methyl (3E)-1-acetyl-3-[methoxy(phenyl)methylidene]-2-oxoindole-6-carboxylate;(E)-1-Acetyl-3-(methoxy(phenyl)methylene)-2-oxoindole-6-carboxylatemethylester;Methyl (3E)-1-acetyl-3-[methoxy(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate;1-Acetyl-3-(methoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester
CBNumber:
CB52625000
???:
C20H17NO5
??? ??:
351.35
MOL ??:
1168152-07-5.mol

(E)-??1-???-3-(???(??)???)-2-?????-6-??????? ??

???
226 - 229°C
?? ?
547.7±50.0 °C(Predicted)
??
1.304±0.06 g/cm3(Predicted)
?? ??
2-8°C
???
?????(?? ???), ???(?? ???)
?? ?? (pKa)
-2.33±0.20(Predicted)
??? ??
??
??? ??
??? ??
??
??????? ????????
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(GHS): GHS hazard pictogramsGHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
H312 ??? ???? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H332 ???? ??? ?? ?? ?? ?? ?? 4 ?? GHS hazard pictograms P261, P271, P304+P340, P312
H341 ???? ??? ??? ??? ??? (????? ???? ????? ???? ???? ???? ??? ?? ????? ??? ???? ??) ???? ???? ?? ?? 2 ?? P201,P202, P281, P308+P313, P405,P501
??????:
P201 ?? ? ?? ???? ?????.
P202 ?? ?? ?? ??? ?? ???? ??? ???? ???.
P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P271 ?? ?? ??? ? ?? ???? ?????.
P280 ????/???/???/?????? ?????.
P281 ???? ?? ???? ?????
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P302+P352 ??? ??? ??? ?? ????.
P304+P340 ???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P308+P313 ?? ?? ??? ???? ???? ??· ??? ????.
P312 ???? ??? ????(??)? ??? ????.
P322 ?? ??(??? … ??)
P330 ?? ?????.
P363 ?? ??? ??? ??? ?????.
P405 ???? ?????.
P501 ...? ??? / ??? ?? ???.

(E)-??1-???-3-(???(??)???)-2-?????-6-??????? C??? ??, ??, ??

(E)-??1-???-3-(???(??)???)-2-?????-6-??????? ?? ?? ? ???

???

??2-????-6-??????? ??1-???-2-?????-6-??????? Trimethyl orthobenzoate

?? ??

Nintedanib

(E)-??1-???-3-(???(??)???)-2-?????-6-??????? ?? ??

???( 64)?? ??
??? ?? ??? ?? ?? ? ??
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