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2-???????????

2-???????????
2-??????????? ??? ???
?? ??:
318465-73-5
???:
2-???????????
???(??):
2-???????????
???:
2-Carboxybenzoyl Amlodipine
???(??):
Amlodipine-8;Amlodipine EP Imp H;AMlodipine iMpurity H;Amlodipine EP Impurity I;AMlodipine EP IMpurity H;Amlodipine impurities1746;AMlodipine IMpurity H (EP);2-Carboxybenzoyl Amlodipine;Amlodipine Besilate Impurity H;Amlodipine Besilate EP Impurity H
CBNumber:
CB52507887
???:
C28H29ClN2O8
??? ??:
556.99
MOL ??:
318465-73-5.mol

2-??????????? ??

???
160-162°C
?? ?
727.6±60.0 °C(Predicted)
??
1.305±0.06 g/cm3(Predicted)
?? ??
Refrigerator
???
DMSO(?? ???), ???(?? ???, ??)
?? ?? (pKa)
3.49±0.36(Predicted)
??? ??
??
??? ??
??? ??
??
???? ?????
??????(pH)
4.94 at 27.1℃ and 1000g/L
LogP
23 at 25℃
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(GHS): GHS hazard pictogramsGHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H317 ????? ?? ??? ??? ? ?? ?? ??? ?? ?? 1 ?? GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H373 ??? ?? ?? ???? ??(??, ??? ?? ??? ?? ??? ??)? ??? ??? ? ?? ?? ???? ?? - ?? ?? ?? 2 ?? P260, P314, P501
H402 ????? ??? ?? ????? ?? - ?? ?? 3
H412 ??? ??? ?? ????? ??? ?? ????? ?? - ?? ?? 3 P273, P501
??????:
P260 ??·?·??·???·??·...·????? ???? ???.
P261 ??·?·??·???·??·...·????? ??? ????.
P272 ??? ??? ??? ??? ???? ???.
P273 ???? ???? ???.
P280 ????/???/???/?????? ?????.
P302+P352 ??? ??? ??? ?? ????.
P314 ???? ??? ???? ??·??? ????.
P321 (…) ??? ???.
P333+P313 ????? ?? ??? ???? ???? ??·??? ????.
P363 ?? ??? ??? ??? ?????.
P501 ...? ??? / ??? ?? ???.

2-??????????? C??? ??, ??, ??

??

As Amlodipine Besilate (A633500) impurity, 2-Carboxybenzoyl AMlodipine can be used in the process for preparing Amlodipine benzenesulfonate.

2-??????????? ?? ?? ? ???

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?? ??


2-??????????? ?? ??

???( 115)?? ??
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