ChemicalBook >?? ???? >4-(2-??????-2-????)-2-????-N-??????

4-(2-??????-2-????)-2-????-N-??????

4-(2-??????-2-????)-2-????-N-?????? ??? ???

?? ??:: 915087-32-0

???:: 4-(2-??????-2-????)-2-????-N-??????

???(??):: 4-(2-??????-2-????)-2-????-N-??????

???:: 4-(2-CYANOPROPAN-2-YLAMINO)-2-FLUORO-N-METHYLBENZAMIDE

???(??):: Enzalutamide Impurity 19;4-((2-Cyanopropan-2-Yl)Amino)-2-Fluoro-N-Methylbenzami;4-(2-CYANOPROPAN-2-YLAMINO)-2-FLUORO-N-METHYLBENZAMIDE;4-[(1-Cyano-1-Methylethyl)aMino]-2-fluoro-N-MethylbenzaMide;4. 4-((2-cyanopropan-2-yl)aMino)-2-fluoro-N-MethylbenzaMide;methylamino 4-[(1-cyano-1-methylethyl)amino]-2-fluorobenzoate;BenzaMide, 4-[(1-cyano-1-Methylethyl)aMino]-2-fluoro-N-Methyl-;"N-Methyl-2-fluoro-4-(1,1-dimethyl cyanomethyl) aminobenzamide";methylbenzamide 4 - ( ( 2 - Cyanopropan - 2 - yl ) amino ) -2 - fluoro - N

CBNumber:: CB52452691

???:: C12H14FN3O

??? ??:: 235.26

MOL ??:: 915087-32-0.mol

?? ?? 92

4-(2-??????-2-????)-2-????-N-?????? ??

?? ?: 413.6±45.0 °C(Predicted)

??: 1?+-.0.06 g/cm3(Predicted)

?? ?? (pKa): 14.29±0.46(Predicted)

?? ? ?? ??
?? ? ???? ?? (GHS)

????(GHS):

?? ?:

Warning

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	P- ??
H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??	P264, P280, P305+P351+P338,P337+P313P
H335	?? ???? ??? ? ??	?? ???? ?? - 1? ??;???? ??	?? 3	??

??????:

P264	?? ??? ?? ??? ????.
P264	?? ??? ?? ??? ????.
P280	????/???/???/?????? ?????.
P302+P352	??? ??? ??? ?? ????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P321	(…) ??? ???.
P332+P313	?? ??? ??? ???? ??· ??? ????.
P362	??? ??? ?? ?? ?? ?????

4-(2-??????-2-????)-2-????-N-?????? C??? ??, ??, ??

??

4-?(2-?Cyanopropan-?2-?ylamino)?-?2-?fluoro-?N-?methylbenzamide is used in the preparation and structural activity relationship of thiohydantoin androgen receptor antagonists for castration-resistant prostate cancer. Also, in the preparation of imidazolidinedione compounds as androgen receptor antagonists useful for the treatment of diseases.

4-(2-??????-2-????)-2-????-N-?????? ?? ?? ? ???

???

2-Fluoro-4-nitrobenzoic acid 2-????-N-??-4-??????? 4-???-2-????-N-?????? 4-???-2-????-N-??????? 2-AMINO-2-METHYL-PROPIONITRILE ????????? ????????? 2-Fluoro-4-nitrotoluene ???

?? ??

4-(2-??????-2-????)-2-????-N-?????? ?? ??

???( 92)?? ??

???	??	???	??	?? ?	??
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4-(2-??????-2-????)-2-????-N-?????? ?? ??:

4-amino-2-fluoro-N-methylbenzamide Enzalutamide EnzalutaMide IMpurity methyl 2-fluoro-4-((1-methoxy-2-methyl-1-oxopropan-2-yl)amino)benzoate 4-Bromo-2-fluorobenzoic acid 4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-N-methylbenzamide 4-[3-[4-Cyano-3-(trifluoroMethyl)phenyl]-5,5-diMethyl-4-oxo-2-thioxo-1-iMidazolidinyl]-2-fluoro-N-(Methyl-d3)benzaMide Enzalutamide Methyl 4-bromo-2-fluorobenzoate Enzalutamide carboxylic acid N-desMethyl EnzalutaMide [2H6]-Enzalutamide Enzalutamide Impurity 7 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Enzalutamide Impurity 7 4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N- 4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluorobenzoic acid methyl ester Enzalutamide Impurity 20

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