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6-??????????

6-??????????
6-?????????? ??? ???
?? ??:
55879-47-5
???:
6-??????????
???(??):
6-??????????
???:
6-hydroxydexamethasone
???(??):
6-hydroxydexamethasone;6β-hydroxy Dexamethasone;Dexamethasone Impurity 12;Dexamethasone 6β-Hydroxy Impurity;Dexamethasone 6beta-Hydroxy Impurity;6-Hydroxydexamethasone Solution, 100ppm;(6R,8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-6,11,17-trihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
CBNumber:
CB51341435
???:
C22H29FO6
??? ??:
408.46
MOL ??:
55879-47-5.mol

6-?????????? ??

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259-262°C
?? ?
613.2±55.0 °C(Predicted)
??
1.38±0.1 g/cm3(Predicted)
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-20°C Freezer
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?? ?? (pKa)
12.06±0.70(Predicted)
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6-?????????? C??? ??, ??, ??

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6β-hydroxy Dexamethasone is a metabolite of dexamethasone (Item Nos. 11015 | 20340) that is more hydrophilic than the parent compound. Dexamethasone is metabolized by CYP3A4; therefore, quantification of the dexamethasone metabolites, 6α- and 6β-hydroxy dexamethasone, can be used to determine CYP3A4 enzyme activity in humans. The formation of 6-hydroxy dexamethasone metabolites is species-specific, with hamsters producing the highest amount. In rats, dexamethasone hydroxylation is sex-specific, with male rats producing metabolites in similar ratios to humans and female rats producing fewer hydroxylated metabolites than male rats.

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The hydrophilic metabolite of Dexamethasone (D298800).

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