Fosinopril sodium, an ester prodrug of fosinoprilat, is the first of a new generation of
phosphinic acid ACE inhibitors indicated for the once-daily treatment of hypertension.
Unlike captopril and lisinopril, it is reportedly effective in increasing the left
ventricular peak filling rates and peak ejection rates in hypertensive patients at rest.
Another advantage is that fosinopril sodium is metabolized equally by renal and hepatic
routes, thereby avoiding the requirement to modify dosage in patients with renal
insufficiency.
??? ??
White to Off-White Crystalline Solid
??
Fosinopril sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.
??
ChEBI: The sodium salt of fosinopril. It is used for the treatment of hypertension and heart failure. A pro-drug, its phosphinate ester group is hydrolysed in vivo to give the corresponding phosphininc acid, fosinoprilat, which is the active metaboli
e.
?? ??
Fosinopril sodium, (4S)-4-cyclohexyl-1-[[[(RS)-1-hydroxy-2-methylpropoxy](4-phenylbutyl)phosphinyl]acetyl]-L-proline sodium salt (Monopril),is a phosphorus-containing ACE inhibitor. It is inactive butserves as a prodrug, being completely hydrolyzed by intestinaland liver enzymes to the active diacid fosinoprilat.
