tert-??2,6-????????????
tert-??2,6-???????????? ??? ???
?? ??:
75308-46-2
???:
tert-??2,6-????????????
???(??):
tert-??2,6-????????????
???:
tert-Butyl 2,6-dichloroisonicotinate
???(??):
TERT-BUTYL 2,6-DICHLOROISONICOTINATE;tert-Butyl 2,6-Dichloroisonicotinate >tert -Butyl 2,6-Dichloroisonicotinate;2,6-Dichloroisonicotinic Acid t-butyl ester;tert-Butyl 2,6-Dichloropyridine-4-carboxylate;tert-Butyl 2,6-dichloro-4-pyridinecarboxylate;2,6-Dichloroisonicotinic acid tert-butyl ester;2,6-dichloro-4-pyridinecarboxylic acid tert-butyl ester;2,6-dichloro-4-pyridinecarboxylic acid 1,1-dimethylethyl ester;4-Pyridinecarboxylic acid, 2,6-dichloro-, 1,1-dimethylethyl ester
CBNumber:
CB4669250
???:
C10H11Cl2NO2
??? ??:
248.11
MOL ??:
75308-46-2.mol
tert-??2,6-???????????? ??
???
80.0 to 84.0 °C
?? ?
326°C
??
1.278
???
151°C
?? ??
under inert gas (nitrogen or Argon) at 2-8°C
??? ??
powder to crystal
?? ?? (pKa)
-4.43±0.10(Predicted)
??
White to Light yellow to Light orange
CAS ??????
75308-46-2(CAS DataBase Reference)
tert-??2,6-???????????? C??? ??, ??, ??
Synthesis
To a solution of 2,6-dichloroisonicotinic acid (2 g, 10.4 mmol) in toluene (50 mL) N, N- dimethylformamide di-fert-butil acetal (15 mL, 62.5 mmol) was added under nitrogen atmosphere and mixture heated at 80°C overnight. Ethyl acetate was added, and the organic layer was washed with water and brine, dried (MgS04), filtered and concentrated to yield tert-Butyl 2,6-dichloroisonicotinate (2.34 g, 87 per cent) as a solid.
tert-??2,6-???????????? ?? ?? ? ???
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tert-??2,6-???????????? ?? ??
???( 112)?? ??
Americas 1
Canada 1
China 69
Europe 1
Germany 2
India 4
Japan 1
South Korea 1
The Netherlands 1
United Kingdom 5
United States 26
Global 112
tert-??2,6-???????????? ?? ??:
