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HALOPROGIN

HALOPROGIN ??? ???
?? ??:
777-11-7
???:
HALOPROGIN
???(??):
polik;m1028;halotex;mycilan;mycanden;Fungaclor;haloprogin;NSC-100071;Haloproginum;HALOPROGIN (200 MG)
CBNumber:
CB4501419
???:
C9H4Cl3IO
??? ??:
361.39
MOL ??:
777-11-7.mol

HALOPROGIN ??

???
113-114°
?? ?
477.49°C (rough estimate)
??
1.9350 (estimate)
??? ??
Solid
??
White to off-white

??

??? ?? Xn
?? ???? ?? 22-36/37/38
????? 26-36
RTECS ?? KO1225000
?? LD50 in mice: >3 g/kg orally and s.c.; 510 mg/kg i.p. (Seki, 1963)

HALOPROGIN C??? ??, ??, ??

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Antibacterial.

Indications

Haloprogin is used as an external drug for moderate dermatophyte infections (shingles), and it is effective for superficial candida infections. Synonyms of this drug are halotex, mycilan, micanden, and others.

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3-Iodo-2-propynyl-2,4,5-trichlorophenyl ether (Halotex)crystallizes as white to pale yellow forms that are sparinglysoluble in water and very soluble in ethanol. It is an etherealderivative of a phenol. Haloprogin is used as a 1% cream forthe treatment of superficial tinea infections.
Formulations of haloprogin should be protected fromlight because the compound is photosensitive. Haloprogin isavailable as a solution and a cream, both in a 1% concentration.Haloprogin is probably not the first topical agent thatshould be recommended. Although the cure rates for topicalfungal infections are relatively high, they come at a highprice. The lesion typically worsens before it improves.Inflammation and painful irritation are common.

HALOPROGIN ?? ?? ? ???

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HALOPROGIN ?? ??

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