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Novobiocin

Novobiocin ??? ???
?? ??:
303-81-1
???:
Novobiocin
???(??):
inamycin;pa93;U 6391;novo-r;C05080;albamix;cathocin;robiocina;NOVOBIOCIN;cathomycin
CBNumber:
CB4500553
???:
C31H36N2O11
??? ??:
612.62
MOL ??:
303-81-1.mol
MSDS ??:
SDS

Novobiocin ??

???
170-172 °C
??
D24 -63.0° (c = 1 in ethanol)
?? ?
657.29°C (rough estimate)
??
1.3448
???
1.5800 (estimate)
?? ??
Hygroscopic, -20°C Freezer, Under inert atmosphere
???
DMSO(?? ???), ???(?? ???)
??? ??
??
??? ??
??? ??
?? ?? (pKa)
pKa1 4.3; pKa2 9.1(at 25℃)
??
???? ?? ???
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
WGK ?? 3
HS ?? 2941906000
?? ?? ??? 303-81-1(Hazardous Substances Data)
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
H317 ????? ?? ??? ??? ? ?? ?? ??? ?? ?? 1 ?? GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
??????:
P280 ????/???/???/?????? ?????.

Novobiocin C??? ??, ??, ??

??? ??

A light-yellow to white antibiotic produced by Streptomyces niveus. Available as calcium and sodium salts.

??

Novobiocin is an aminocoumarin antibiotic isolated from a number of species of Streptomyces. Novobiocin exhibits broad spectrum Gram positive activity and was used clinically. Novobiocin is a potent inhibitor of bacterial DNA gyrase and a competitive inhibitor of the ATPase reaction catalysed by GyrB.

??

ChEBI: A coumarin-derived antibiotic obtained from Streptomyces niveus.

World Health Organization (WHO)

Novobiocin, an antibiotic with a narrow spectrum of activity, was introduced in 1956. Its use was subsequently associated with serious adverse effects including blood dyscrasias. In view of its toxicity there are no current valid indications for its use. Although preparations containing novobiocin may remain available in some countries it has largely lapsed into disuse.

???

May have damaging side effects.

Novobiocin ?? ?? ? ???

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SOYBEAN MEAL ??????

?? ??

Novobiocin ?? ??

???( 89)?? ??
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Novobiocin ?? ??:

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