4,6-Dibromo-pyrazolo[1,5-a]pyridine-3-carbonitrile
4,6-Dibromo-pyrazolo[1,5-a]pyridine-3-carbonitrile ??
??
2.12±0.1 g/cm3(Predicted)
?? ??
Sealed in dry,Room Temperature
?? ?? (pKa)
-2.88±0.30(Predicted)
InChI
InChI=1S/C8H3Br2N3/c9-6-1-7(10)8-5(2-11)3-12-13(8)4-6/h1,3-4H
InChIKey
FBKJJSFJKWOLQA-UHFFFAOYSA-N
SMILES
C12=C(C#N)C=NN1C=C(Br)C=C2Br
??
?? ? ?? ??
?? ? ???? ?? (GHS)
????(GHS):
?? ?:
Warning
??·?? ??:
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P- ??
H302 ??? ???
?? ?? ?? - ??
?? 4
??
P264, P270, P301+P312, P330, P501
H315 ??? ??? ???
????? ?? ?????
?? 2
??
P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ???
?? ? ?? ?? ??? ??
?? 2A
??
P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ??
?? ???? ?? - 1? ??;???? ??
?? 3
??
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P280 ????/???/???/?????? ?????.
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P302+P352 ??? ??? ??? ?? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
4,6-Dibromo-pyrazolo[1,5-a]pyridine-3-carbonitrile C??? ??, ??, ??
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4,6-Dibromo-pyrazolo[1,5-a]pyridine-3-carbonitrile is used as a reagent for organic synthesis or as a pharmaceutical intermediate component. It can be used to prepare Selpercatinib, an oral selective inhibitor of tyrosine kinase receptors for the treatment of advanced RET mutant medullary thyroid carcinoma (MTC) and advanced RET fusion-positive non-small cell lung cancer (NSCLC).
4,6-Dibromo-pyrazolo[1,5-a]pyridine-3-carbonitrile ?? ?? ? ???
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?? ??
4,6-Dibromo-pyrazolo[1,5-a]pyridine-3-carbonitrile ?? ??
???( 40)?? ??
China 37
India 1
United States 2
Global 40
4,6-Dibromo-pyrazolo[1,5-a]pyridine-3-carbonitrile ?? ??:
