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4-???-N-(4-?????-1-?????)-3-???-???????

4-???-N-(4-?????-1-?????)-3-???-???????
4-???-N-(4-?????-1-?????)-3-???-??????? ??? ???
?? ??:
420092-79-1
???:
4-???-N-(4-?????-1-?????)-3-???-???????
???(??):
4-???-N-(4-?????-1-?????)-3-???-???????
???:
4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide
???(??):
SW155246;SW155246 >=98% (HPLC);SW155246, 10 mM in DMSO;4-chloro-N-(4-hydroxynaphthalen- 1-yl)-3-nitrobenzenesulfonamide;4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide;Benzenesulfonamide, 4-chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-;SW 155246,cancer,hDNMT1,DNMTs,DNMT1 inhibitor,SW155246,Inhibitor,SW-155246,inhibit,mDNMT3A,DNA MTases,DNA Methyltransferase
CBNumber:
CB42751098
???:
C16H11ClN2O5S
??? ??:
378.79
MOL ??:
420092-79-1.mol

4-???-N-(4-?????-1-?????)-3-???-??????? ??

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2-8°C
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DMSO: ???10mg/mL, ??
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  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xi
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????? 26
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
??????:
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
NFPA 704
0
2 0

4-???-N-(4-?????-1-?????)-3-???-??????? C??? ??, ??, ??

??

SW155246 is an inhibitor of DNA methyltransferase 1 (DNMT1; IC50 = 1.2 μM). It is selective for human DNMT1 over murine DNMT3 (IC50 = 38 μM). SW155246 inhibits HeLa and A549 tumor cell growth in a redox-independent manner (IC50s = 8-20 μM). It also inhibits genomic methylation in HeLa cells when used at concentrations ranging from 10 to 18.6 μM.

4-???-N-(4-?????-1-?????)-3-???-??????? ?? ?? ? ???

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4-???-N-(4-?????-1-?????)-3-???-??????? ?? ??

???( 54)?? ??
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4-???-N-(4-?????-1-?????)-3-???-??????? ?? ??:

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