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ERDAFITINIB

ERDAFITINIB ??? ???

?? ??:: 1346242-81-6

???:: ERDAFITINIB

???(??):: JNJ-42756493;CS-2043;Erdafitinib;erdafitnnib;Suftalan Zine;Erdafitinib-d6;2H6]-Erdafitinib;Erdafitinib(JNJ-42756493);JNJ-42756493 (Erdafitinib);Erdafitinib, 10 mM in DMSO

CBNumber:: CB42725628

???:: C25H30N6O2

??? ??:: 446.54

MOL ??:: 1346242-81-6.mol

?? ?? 162

ERDAFITINIB ??

???: 136-140°C

?? ?: 662.3±55.0 °C(Predicted)

??: 1.20±0.1 g/cm3(Predicted)

?? ??: -20°C Freezer, Under inert atmosphere

???: DMSO(?? ???), ???(?? ???)

??? ??: ??

??? ??: ??? ??

?? ?? (pKa): 9.45±0.29(Predicted)

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?? ? ???? ?? (GHS)

????(GHS):

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Danger

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??	??·?? ??	?? ??	??	?? ?	P- ??
H302	??? ???	?? ?? ?? - ??	?? 4	??	P264, P270, P301+P312, P330, P501
H317	????? ?? ??? ??? ? ??	?? ??? ??	?? 1	??	P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H318	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 1	??	P280, P305+P351+P338, P310
H361	?? ?? ????? ??? ??? ??? ???	???? ??	?? 2	??	P201, P202, P281, P308+P313, P405,P501
H372	??? ?? ?? ???? ??(??, ??? ?? ??? ?? ??? ??)? ??? ???	?? ???? ?? - ?? ??	?? 1	??	P260, P264, P270, P314, P501
H413	??? ??? ?? ????? ??? ??? ??	?? ????? ?? - ??	?? 4

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P201	?? ? ?? ???? ?????.
P202	?? ?? ?? ??? ?? ???? ??? ???? ???.
P260	??·?·??·???·??·...·????? ???? ???.
P261	??·?·??·???·??·...·????? ??? ????.
P264	?? ??? ?? ??? ????.
P264	?? ??? ?? ??? ????.
P270	? ??? ??? ??? ???, ???? ???? ???.
P272	??? ??? ??? ??? ???? ???.
P280	????/???/???/?????? ?????.
P281	???? ?? ???? ?????
P301+P312	??? ???? ??? ????(??)? ??? ????.
P302+P352	??? ??? ??? ?? ????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P308+P313	?? ?? ??? ???? ???? ??· ??? ????.
P310	?? ????(??)? ??? ????. ???? ?? ????(??)? ??? ????.
P314	???? ??? ???? ??·??? ????.
P321	(…) ??? ???.
P330	?? ?????.
P333+P313	????? ?? ??? ???? ???? ??·??? ????.
P363	?? ??? ??? ??? ?????.
P405	???? ?????.
P501	...? ??? / ??? ?? ???.

NFPA 704

	0
3		0

ERDAFITINIB C??? ??, ??, ??

??

Erdafitinib is an oral pan-FGFR (1-4) inhibitor with has demonstrated promising activity in patients with metastatic or unresectable UC and other histologies (eg, cholangiocarcinoma) with FGFR alterations. It is used in the therapy of locally advanced, unresectable or metastatic urothelial carcinoma. Erdafitinib has been associated with a high rate of serum enzyme elevations during therapy, but has not been linked to cases of clinically apparent acute liver injury.

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In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations, that has progressed during or following platinum-containing chemotherapy, including within 12 months of neoadjuvant or adjuvant platinum-containing chemotherapy. At the same time, the FDA also approved the therascreen FGFR RGQ RT-PCR Kit (Qiagen) for utilization as a companion diagnostic with erdafitinib for selecting patients for the indicated therapy.

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Erdafitinib is a fibroblast growth factor receptor inhibitor.

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Balversa

ERDAFITINIB ?? ?? ? ???

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ERDAFITINIB ?? ??

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???	??	???	??	?? ?	??
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ERDAFITINIB ?? ??:

Panitumumab

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