Masitinib
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Masitinib ??
- ???
- 90-95°C
- ??
- 1.280±0.06 g/cm3(Predicted)
- ?? ??
- Refrigerator
- ???
- ?????(?? ???), ??????(?? ???), DMSO(?? ???), ???(?? ???)
- ??? ??
- ??
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 13.24±0.70(Predicted)
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- ?? ? ???? ?? (GHS)
Masitinib C??? ??, ??, ??
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Off-White to Pale Yellow Solid??
Masitinib is a novel tyrosine kinase inhibitor (TKI) being developed by AB Science to treat symptoms of amyotrophic lateral sclerosis (ALS). Masitinib controlled-release implant for treating solid neoplasm.??
ChEBI: Masitinib is a member of the class of benzamides that is the carboxamide resulting from the formal condensation of the carboxy group of 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid with the primary amino group of 4-methyl-N(3)-[4-(pyridin-3-yl)-1,3-thiazol-2-yl]benzene-1,3-diamine. It is a highly selective oral tyrosine kinase inhibitor. It has a role as a tyrosine kinase inhibitor, an antineoplastic agent and an antirheumatic drug. It is a N-alkylpiperazine, a member of 1,3-thiazoles, a member of pyridines and a member of benzamides.???
Masitinib is relatively well tolerated with the most common side effects being asthenia (loss of strength and/or energy), rash, nausea, oedema (fluid retention) and diarrhoea.Masitinib ?? ?? ? ???
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4-Methyl-n3-(4-pyridin-3-yl-thiazol-2-yl)-benzene-1,3-diaMine
4-(4-Methylpiperazin-1-ylmethyl)benzoyl chloride
METHYL 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZOATE
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Masitinib ?? ??
???( 247)?? ??
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