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RP-8-???-??-??-1,N2-???????3',5'-????????????????????

RP-8-???-??-??-1,N2-???????3',5'-????????????????????
RP-8-???-??-??-1,N2-???????3',5'-???????????????????? ??? ???
?? ??:
185246-32-6
???:
RP-8-???-??-??-1,N2-???????3',5'-????????????????????
???(??):
RP-8-???-??-??-1,N2-???????3',5'-????????????????????
???:
RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE
???(??):
Rp 8 Br PET cGMPS,Rp8BrPETcGMPS;Rp-8-bromo-PET-Cyclic GMPS sodium;Rp-8-bromo-PET-Cyclic GMPS (sodium salt);RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'...;Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate;Rp-8-Bromo-beta-phenyl-1,N2-ethenoguanosine 3',5'-cyclic monophosphorothioate sodium salt;RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE;Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3μ:5μ-cyclic monophosphorothioate hydrate sodium salt;Rp-8-Bromo-beta-phenyl-1,N2-ethenoguanosine 3',5'-cyclic monophosphorothioate sodium salt >=98% (HPLC), powder;Rp-8-Br-PET-cGMPS hydrate, Rp-β-Phenyl-1,N2-etheno-8-bromoguanosine 3μ,5μ-cyclic monophosphorothioate hydrate sodium salt
CBNumber:
CB3972375
???:
C18H14BrN5NaO6PS
??? ??:
562.266
MOL ??:
185246-32-6.mol
MSDS ??:
SDS

RP-8-???-??-??-1,N2-???????3',5'-???????????????????? ??

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240-300 °C(lit.)
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-20°C
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H2O: 60°C ???? ??? 15mg/mL
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H2O: 15mg/mL at≤60°C

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????? 22-24/25
WGK ?? 3

RP-8-???-??-??-1,N2-???????3',5'-???????????????????? C??? ??, ??, ??

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Rp-8-bromo-PET-Cyclic GMPS (Rp-8-bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (Kis = 35 and 30 nM). It less potently inhibits protein kinase A (Ki = 11 μM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC50 = 25 μM). In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI (Ki = 1 μM). Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11.

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Rp-8-Br-PET-cyclic GMPS Sodium Salt is a competitive inhibitor of cGMP-dependent protein kinase (cGKI).

Biochem/physiol Actions

Rp-8-Br-PET-cGMPS is metabolically stable, competitive inhibitor of cGMP-dependent protein kinase G. Inhibits both PKG I (Ki?=?30 nM) and PKG II and blocks cGMP-gated retinal type ion channels (IC50?=?25 micromoles).

RP-8-???-??-??-1,N2-???????3',5'-???????????????????? ?? ?? ? ???

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RP-8-???-??-??-1,N2-???????3',5'-???????????????????? ?? ??

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