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SGC0946

SGC0946 ??? ???
?? ??:
1561178-17-3
???:
SGC0946
???(??):
sg946;CS-1937;CS-1475;SGC0946;SGC0946 USP/EP/BP;SGC0946, 10 mM in DMSO;1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahy;5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-7H-Pyrrolo[2,3-;5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylEthyl)phenyl]amino]carbonyl]amino]propyl](1-methylEthyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine;7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 5-bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-
CBNumber:
CB32645673
???:
C28H40BrN7O4
??? ??:
618.57
MOL ??:
1561178-17-3.mol
MSDS ??:
SDS

SGC0946 ??

???
125-126o C
?? ?
771.5±60.0 °C(Predicted)
??
1.48±0.1 g/cm3(Predicted)
?? ??
-20°C
???
DMSO: ???20mg/mL, ??
?? ?? (pKa)
12.39±0.70(Predicted)
??? ??
??
??
???? ????
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  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? T
?? ???? ?? 25
????? 45
????(UN No.) UN 2811 6.1 / PGIII
WGK ?? 3
HS ?? 2934999090
????(GHS): GHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H301 ??? ??? ?? ?? ?? - ?? ?? 3 ?? GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
??????:
P301+P310 ???? ?? ????(??)? ??? ????.
NFPA 704
0
2 0

SGC0946 C??? ??, ??, ??

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SGC0946 is a potent DOT1L methyltransferase inhbiitor used in the treatment of leukemia seen effectively in vitro.

Biochem/physiol Actions

SGC0946 is a potent and selective inhibitor of Histone H3-lysine79 (H3K79) methyltransferase DOT1L with an IC50 of 0.3 nM in a radioactive enzyme assay, and over 100-fold selectivity for DOT1L over other histone methyltransferases. In cell studies, SGC0946 reduces H3K79 dimethylation with an IC50 of 2.6 nM in A431 cells and 8.8 nM in MCF10A cells. SGC0946 was found to selectively kills cells transformed with the MLL-AF9 fusion oncogene in an in vitro model of leukemia. For full characterization details, please visit the SGC0946 probe summary on the Structural Genomics Consortium (SGC) website.SGC0649 is the negative control for the active probe, SGC0946. To request a sample of the negative control from the SGC, click here.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

SGC0946 ?? ?? ? ???

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SGC0946 ?? ??

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SGC0946 ?? ??:

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