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Eurycomanone

Eurycomanone ??? ???
?? ??:
84633-29-4
???:
Eurycomanone
???(??):
NSC 339187;eurysanone;EURYCOMANONE;pasakbumin-a;tonkat ali extract;Eurycoma longifolia;Eurycomanone (~90%);Broad tassel ketone;EurycomalongifoliaJack;Eurycomanone - Bio-X ?
CBNumber:
CB3189926
???:
C20H24O9
??? ??:
408.4
MOL ??:
84633-29-4.mol
MSDS ??:
SDS

Eurycomanone ??

???
273-285℃ (methanol ethyl ether )
?? ?
669.5±55.0 °C(Predicted)
??
1.63±0.1 g/cm3(Predicted)
?? ??
-20°C Freezer
???
DMSO (?? ???), ???(?? ???,??, ??? ??)
??? ??
??
??? ??
??? ??
?? ?? (pKa)
11.29±0.70(Predicted)
??
???? ?? ?????
???? ??
plant
InChIKey
RRXCMOJNEHOTBC-OHYAWSEYNA-N
SMILES
[C@]123CO[C@@]4(O)[C@H](O)C(=C)[C@]1(O)[C@@H](O)C(=O)O[C@]2([H])C[C@@]1([H])C(C)=CC(=O)[C@@H](O)[C@]1(C)[C@]34[H].O.O |&1:0,3,5,9,11,16,19,26,28,30,r|
??
  • ?? ? ?? ??
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
??????:
NFPA 704
0
2 0

Eurycomanone C??? ??, ??, ??

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Eurycomanone is known as a cytotoxic compound found in Eurycoma Longifolia Jack. Previous studies had noted its cytotoxic effects against various cancer cell lines. More recent research demonstrated the ability of Eurycomanone to suppress the expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28. Eurycomanone was shown to also exerts the ability to induce apoptosis through the up-regulation of p53 in human cervical carcinoma cells.

??

ChEBI: A quassinoid isolated from Eurycoma longifolia and has been shown to exhibit antineoplastic and antimalarial activties.

Manufacturing Process

The extraction and purification process of eurycomanone in a kind of Tongkat Ali plant:
The preparation of the first medicinal extract: Tongkat Ali tree root meal is gone out eurycomanone with solvent extraction, extracting solution, concentrating under reduced pressure obtains Tongkat Ali medicinal extract.
Second degreasing: by Tongkat Ali medicinal extract with petroleum ether extraction, leaves standstill, layering. The low-pole compositions include removing fat-soluble pigment.
3rd extracting and separating: the medicinal extract after petroleum ether degreasing with extraction into ethyl acetate, obtain the ethyl acetate solution of eurycomanone.
4th pillar layer separation: the ethyl acetate solution of eurycomanone is separated with silica gel column chromatography, obtaining the elutriant containing eurycomanone.
5th decolouring: the composition containing eurycomanone is activated carbon decolorizing.
6th concentrates and crystallization: the destainer concentrates under reduced pressure of eurycomanone, and crystallization obtains the crude product eurycomanone.
7th purifying: add sherwood oil in crude product eurycomanone, then drip a little ethyl acetate, by the impurity pigment washing removing on crystallisate, obtain the xln of white.
8th filters, dry: by the vacuum-drying of eurycomanone xln.

Eurycomanone ?? ?? ? ???

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Eurycomanone ?? ??

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Eurycomanone ?? ??:

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