ChemicalBook >?? ???? >5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione
5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione
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5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione ??
- ???
- 117 °C (decomp)
- ?? ?
- 489.0±45.0 °C(Predicted)
- ??
- 1.462±0.06 g/cm3(Predicted)
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- under inert gas (nitrogen or Argon) at 2-8°C
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- ?????(?? ???), ???????(?? ???), ???(?? ???)
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- ?? ?? (pKa)
- 4.50±1.00(Predicted)
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- ?? ? ???? ?? (GHS)
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5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione C??? ??, ??, ??
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White to Off-white Solid.??
5-[1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione is an impurity of the DPP-IV inhibitor Sitagliptin (S491000).?? ??
5-[1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene] is an intermediate for the synthesis of sitagliptin. Sitagliptin is a new type of anti-type II diabetes drug approved by the FDA and the first dipeptidyl peptidase-IV inhibitor drug for the treatment of type II diabetes.5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione ?? ?? ? ???
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5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione ?? ??
???( 103)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 18750 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21634 | 55 |
| Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 |
chloewu@chicopharm.cn | CHINA | 340 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29880 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14332 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49374 | 58 |
| SIMAGCHEM CORP | +86-13806087780 |
sale@simagchem.com | China | 17365 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 |
sales@afinechem.com | China | 15352 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | China | 52849 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 |
sales@huarongpharm.com | CHINA | 3148 | 58 |
5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione ?? ??:
Sitagliptin Impurity 28
Sitagliptin Impurity 46
Sitagliptin Impurity 77
Sitagliptin impurity 5
Methyl 3-aMino-4-(2,4,5-trifluorophenyl)butanoate
ethyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate
2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE
Sitagliptin Impurity 34
2,4,5-TRIFLUOROBENZYL CHLORIDE
(R)-methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate
Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,Methylester,(bR)-
Sitagliptin
Sitagliptin Impurity 14
Sitagliptin Defuoro IMpurity 5
Sitagliptin DeaMino IMpurity 1
(S)-Sitagliptin Phosphate
2,2,2-TRIFLUORO-N'-(TRIFLUOROACETYL)ACETOHYDRAZIDE
(R)-10-(2,4,5-trifluorobenzyl)-3-(trifluoromethyl)-6,7,10,11-tetrahydro-[1,2,4]triazolo[3,4-c][1,4,7]triazecine-8,12(5H,9H)-dione