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Purmorphamine

Purmorphamine ??? ???
?? ??:
483367-10-8
???:
Purmorphamine
???(??):
CS-1816;Purmorphamin;PURMORPHAMINE;Purmorphamine, >=98%;Purmorphamine USP/EP/BP;Shh Signaling Antagonist VI;Purmorphamine, 10 mM in DMSO;Purmorphamine, Smoothened receptor agonist;inhibit,Purmorphamine,Autophagy,Smo,Smoothened,Inhibitor;2-(1-NAPHTHOXY)-6-(4-MORPHOLINOANILINO)-9-CYCLOHEXYLPURINE
CBNumber:
CB2841106
???:
C31H32N6O2
??? ??:
520.62
MOL ??:
483367-10-8.mol
MSDS ??:
SDS

Purmorphamine ??

???
210-212°C
?? ?
790.3±70.0 °C(Predicted)
??
1.35±0.1 g/cm3(Predicted)
?? ??
-20°C
???
DMSO: ???5mg/mL, ??(??)
?? ?? (pKa)
5.44±0.40(Predicted)
??? ??
??
??
???? ????
???
??? ?? ?????? 1? ?? ??????. DMSO ??? -20°C?? ?? 3?? ?? ??? ? ????.
InChIKey
FYBHCRQFSFYWPY-UHFFFAOYSA-N
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
WGK ?? 3
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H341 ???? ??? ??? ??? ??? (????? ???? ????? ???? ???? ???? ??? ?? ????? ??? ???? ??) ???? ???? ?? ?? 2 ?? P201,P202, P281, P308+P313, P405,P501
??????:
P201 ?? ? ?? ???? ?????.
P202 ?? ?? ?? ??? ?? ???? ??? ???? ???.
P280 ????/???/???/?????? ?????.
P308+P313 ?? ?? ??? ???? ???? ??· ??? ????.
P405 ???? ?????.
P501 ...? ??? / ??? ?? ???.

Purmorphamine C??? ??, ??, ??

??

Small molecules that promote osteoblast differentiation might be useful as therapeutic agents for bone diseases such as osteoporosis. Purmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts. The EC50 value for differentiation of C3H10T1/2 cells based on alkaline phosphatase expression is 1 μM. Investigation into purmorphamine’s mechanism of action indicates that it directly binds to and activates the 7-transmembrane Smo receptor of the Hedgehog signaling pathway.

??? ??

Light Tan Solid

??

Purmorphamine has been used to study the consequences of upregulation of Hedgehog signalling pathway in Tupfel long fin strain Zebrafish.

??

ChEBI: A member of the class of purines that is purine substituted at C-2 by a 1-naphthyloxy group, at C-4 by a 4-morpholinophenylamino group, and at N-9 by a cyclohexyl group.

Purmorphamine ?? ?? ? ???

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Purmorphamine ?? ??

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Purmorphamine ?? ??:

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