???? ????
|
|
???? ???? ??
- ???
- 75-78 °C(lit.)
- ?? ?
- 185-186 °C(lit.)
- ??
- 1.2085 (rough estimate)
- ???
- 1.4340 (estimate)
- ???
- 185-186°C
- ?? ??
- Inert atmosphere,Room Temperature
- ???
- ?????(?? ???), ???(?? ???)
- ?? ?? (pKa)
- 9.32±0.10(Predicted)
- ??? ??
- ??? ??
- ??
- ???? ?? ??
- ??
- ?? ??
- ???
- 5g/100mL(20℃)
- ??
- Hygroscopic
- BRN
- 605582
- ???
- ????. ?? ???? ???? ????.
- InChIKey
- FSEUPUDHEBLWJY-HWKANZROSA-N
- CAS ??????
- 57-71-6(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38-20/21/22 | ||
| ????? | 22-24/25-36/37/39-26 | ||
| WGK ?? | 3 | ||
| RTECS ?? | EK3150000 | ||
| TSCA | Yes | ||
| HS ?? | 29280090 | ||
| ?? | LD50 ipr-mus: 51 mg/kg JPMSAE 53,1143,64 | ||
| ???? ?? | KE-03825 |
???? ???? C??? ??, ??, ??
??? ??
white crystals??
2,3-Butanedione monoxime is a reversible inhibitor of myosin ATPase. It is also used as a reagent for colorimetric determination of urea.?? ??
Approximately 9 moles of ethyl nitrite are required for this preparation. The literature indicates a suitable apparatus for its generation.In a well-ventilated hood, to freshly dried and distilled methyl ethyl ketone (620 gm, 8.6 moles) is added, with stirring, 40 ml of cone, hydrochloric acid. The temperature of the reaction system is raised to 40°C. Without delay the addition of ethyl nitrite is initiated and the flow of the reagent is regulated to such a rate that the reaction temperature never exceeds 55°C. About 1.5 hr are required for the addition. The ethanol formed in the reaction, as well as unreacted methyl ethyl ketone, is separated by distillation until the pot temperature just reaches 90°C.
The product is separated from the residue by rapid steam distillation. Virtually all of the product will be found in the first 5 liters of the distillate. The distillate is saturated with 1.5 kg of sodium chloride and cooled to 0°C. The product, which precipitates out, is filtered off. If necessary, the product may be recrystallized from water to afford 500 gm (58%), m.p. 76.5°C.
?? ??
Cream-colored powder.??? ?? ??
Soluble in water.?? ???
2,3-Butanedione monoxime may react violently during vacuum distillation above 130 pascals.????
Flash point data for 2,3-Butanedione monoxime are not available, but 2,3-Butanedione monoxime is probably combustible.Safety Profile
Poison by intraperitoneal route. When heated to decomposition it emits toxic vapors of NOx.???? ???? ?? ?? ? ???
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???? ???? ?? ??
???( 366)?? ??
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