ChemicalBook >?? ???? >BenzaMide,N-1H-???[2,3-c]???-5-?-
BenzaMide,N-1H-???[2,3-c]???-5-?-
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![BenzaMide,N-1H-???[2,3-c]???-5-?-](CAS/GIF/300586-90-7.gif)
BenzaMide,N-1H-???[2,3-c]???-5-?- ??
- ?? ?
- 386.6±22.0 °C(Predicted)
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- 1.363±0.06 g/cm3(Predicted)
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- 2-8°C
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- DMSO: ???20mg/mL, ??
- ?? ?? (pKa)
- 11.76±0.43(Predicted)
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| WGK ?? | 3 | ||
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| HS ?? | 2933.99.8290 |
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| ?? ?: | Warning | |||||||||||||||||||||
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BenzaMide,N-1H-???[2,3-c]???-5-?- C??? ??, ??, ??
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OAC1 enhances iPSC reprogramming efficiency.?? ??
A cell-permeable pyrrolopyridinyl-benzamide compound that is reported to enhance the efficiency of 4F/4TF-induced iPSC generation from MEFs cultured in either feeder cell-containing ESC media or in feeder-/serum-free iSF1 media (1 μM OAC1 treatment starts 48 h after viral transduction). OCA1 is shown to increase cellular Oct4, Nanog, Sox2, and Tet1 mRNA levels via a yet unidentified mechanism, although OAC1 is reported not affect Oct4 promoter methylation, cellular Wnt signaling, or p53 and p21 mRNA levels. Six other iPSC reprogramming improving reagents, AM580, AzaC, BIX-01294 (Cat. No. 382190), Tranylcypromine (Cat. No. 616431), VPA (Cat. No. 676380), and Vitamin C (Cat. No. 1813), in comparison, do not exhibit Oct4 and Nanog promoters enhancing activity, while BIO (Cat. No. 361550) is demonstrated to be 3.8- and 6-fold less potent than OAC1, respectively, in inducing Oct4 and Nanog transcription.Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Biochem/physiol Actions
Cell permeable: yesBenzaMide,N-1H-???[2,3-c]???-5-?- ?? ?? ? ???
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BenzaMide,N-1H-???[2,3-c]???-5-?- ?? ??
???( 113)?? ??
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