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??,2,2'-?????[3,4,6-?????]-

??,2,2'-?????[3,4,6-?????]-
??,2,2'-?????[3,4,6-?????]- ??? ???
?? ??:
1638-41-1
???:
??,2,2'-?????[3,4,6-?????]-
???(??):
??,2,2'-?????[3,4,6-?????]-
???:
PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-
???(??):
p38 MAPK Inhibitor IV;p38 MAP Kinase Inhibitor IV;p38 MAP Kinase Inhibitor IV (B10);2,2'-Sulfonylbis(3,4,6-trichlorophenol);PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-;p38 MAP Kinase Inhibitor IV,p-38 MAP Kinase Inhibitor IV;p38 MAP Kinase Inhibitor IV - CAS 1638-41-1 - Calbiochem;Phenol, 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)sulfonyl]-
CBNumber:
CB22446185
???:
C12H4Cl6O4S
??? ??:
456.94
MOL ??:
1638-41-1.mol
MSDS ??:
SDS

??,2,2'-?????[3,4,6-?????]- ??

???
244-245 °C(Solv: ethyl acetate (141-78-6))
?? ?
590.0±50.0 °C(Predicted)
??
1.854±0.06 g/cm3(Predicted)
?? ??
2-8°C
???
DMSO: ???5mg/mL, ??(??)
??? ??
??
?? ?? (pKa)
2.43±0.50(Predicted)
??
???? ????

??

WGK ?? 3

??,2,2'-?????[3,4,6-?????]- C??? ??, ??, ??

??

p38 MAP Kinase Inhibitor IV is an ATP-competitive p38α/β MAPK inhibitor.

?? ??

A cell-permeable symmetrical sulfone compound that acts as a potent and ATP-competitive inhibitor of p38α/β MAPK (IC50 = 130 and 550 nM, respectively), while exihibiting much reduced activity (≤23% inhibition at 1 μM) against p38γ/δ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203850 (Cat. Nos. 559389, 559395, and 559398) in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM respective inhibitor).

Biochem/physiol Actions

p38 MAP Kinase Inhibitor IV is an ATP-competitive inhibitor of p38α/β MAPK with IC50 values of 130 nM for p38α and 550 nM for p38β. It is much less active with ≤23% inhibition at 1 μM against p38γ/σ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203580 in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM inhibitor). A recent study showed that p38 MAP Kinase Inhibitor IV could consistently and significantly enhance reprogramming and iPS cell generation from somatic cells.

??,2,2'-?????[3,4,6-?????]- ?? ?? ? ???

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??,2,2'-?????[3,4,6-?????]- ?? ??

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