ChemicalBook >?? ???? >??,2,2'-?????[3,4,6-?????]-
??,2,2'-?????[3,4,6-?????]-
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??,2,2'-?????[3,4,6-?????]- ??
- ???
- 244-245 °C(Solv: ethyl acetate (141-78-6))
- ?? ?
- 590.0±50.0 °C(Predicted)
- ??
- 1.854±0.06 g/cm3(Predicted)
- ?? ??
- 2-8°C
- ???
- DMSO: ???5mg/mL, ??(??)
- ??? ??
- ??
- ?? ?? (pKa)
- 2.43±0.50(Predicted)
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WGK ?? | 3 |
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??,2,2'-?????[3,4,6-?????]- C??? ??, ??, ??
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p38 MAP Kinase Inhibitor IV is an ATP-competitive p38α/β MAPK inhibitor.?? ??
A cell-permeable symmetrical sulfone compound that acts as a potent and ATP-competitive inhibitor of p38α/β MAPK (IC50 = 130 and 550 nM, respectively), while exihibiting much reduced activity (≤23% inhibition at 1 μM) against p38γ/δ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203850 (Cat. Nos. 559389, 559395, and 559398) in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM respective inhibitor).Biochem/physiol Actions
p38 MAP Kinase Inhibitor IV is an ATP-competitive inhibitor of p38α/β MAPK with IC50 values of 130 nM for p38α and 550 nM for p38β. It is much less active with ≤23% inhibition at 1 μM against p38γ/σ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203580 in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM inhibitor). A recent study showed that p38 MAP Kinase Inhibitor IV could consistently and significantly enhance reprogramming and iPS cell generation from somatic cells.??,2,2'-?????[3,4,6-?????]- ?? ?? ? ???
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??,2,2'-?????[3,4,6-?????]- ?? ??
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CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
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Lynnchem | 86-(0)29-85992781 17792393971 |
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??,2,2'-?????[3,4,6-?????]- ?? ??:
2,2''-????(4,6-??????) 2,2''-????(4-?????)
4-Nitrobenzenesulfonyl chloride
Dichlorophen
1,3-dichloro-5-(methylsulphonyl)benzene
2,3-DICHLOROTHIOPHENOL
3,5-DICHLOROTHIOANISOLE
2-(METHYLSULFONYL)PHENOL
BITHIONOL SULFOXIDE
4-CHLORO-2-[(5-CHLORO-2-HYDROXYPHENYL)SULFONYL]PHENOL
1,4-DICHLORO-2-(METHYLSULFONYL)BENZENE
PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-