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MRS 2578

MRS 2578 ??? ???
?? ??:
711019-86-2
???:
MRS 2578
???(??):
CS-1109;MRS 2578;MRS-2578; MRS2578;MRS 2578 USP/EP/BP;MRS 2578 >=95% (HPLC);MRS 2578, 10 mM in DMSO;MRS 2578;MRS-2578; MRS2578;MRS2578 P2Y6 antagonist MRS-2578;1,4-DI[3-(3-ISOTHIOCYANATOPHENYL)THIOUREIDO]BUTANE;N,N''-1,4-BUTANEDIYLBIS[N'-(3-ISOTHIOCYANATOPHENYL)THIOUREA]
CBNumber:
CB2112787
???:
C20H20N6S4
??? ??:
472.67
MOL ??:
711019-86-2.mol
MSDS ??:
SDS

MRS 2578 ??

???
170 - 173°C
?? ?
652.7±65.0 °C(Predicted)
??
1.31
?? ??
2-8°C
???
DMSO: ~17mg/mL
??? ??
??
??? ??
??? ??
?? ?? (pKa)
11.80±0.70(Predicted)
??
???
InChIKey
QOHNRGHTJPFMSL-UHFFFAOYSA-N
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xn
?? ???? ?? 20/21/22-36/37/38-42
????? 22-26-36/37/39-45
????(UN No.) UN 2811 6.1/PG 3
WGK ?? 3
????(GHS): GHS hazard pictogramsGHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H301 ??? ??? ?? ?? ?? - ?? ?? 3 ?? GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H334 ?? ? ????? ??, ?? ?? ?? ?? ?? ??? ? ?? ??? ??? ?? ?? 1 ?? GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P280 ????/???/???/?????? ?????.
P301+P310 ???? ?? ????(??)? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
NFPA 704
0
3 0

MRS 2578 C??? ??, ??, ??

??

MRS2578 is an antagonist of the purinergic P2Y6 receptor (IC50s = 37 and 98 nM for human and rat receptors, respectively). It is without effect at other purinergic receptors. MRS2578 is used to study the cellular and physiological roles of P2Y6.

??

MRS 2578 is a selective P2Y66?receptor antagonist.

???? ??

Selective antagonist of P2Y 6 nucleotide receptors; IC 50 values are 37 and 98 nM at human and rat P2Y 6 receptors respectively. Displays no activity at P2Y 1 , P2Y 2 , P2Y 4 and P2Y 11 receptors (IC 50 > 10 μ M). Inhibits agonist-induced cardiomyocyte contraction and UDP-induced phagocytosis.

MRS 2578 ?? ?? ? ???

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?? ??

MRS 2578 ?? ??

???( 102)?? ??
??? ?? ??? ?? ?? ? ??
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MRS 2578 ?? ??:

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