?????
|
|
????? ??
- ???
- 195-197°C
- ??
- D20 -71.7° (c = 0.5 in ethanol)
- ?? ?
- 577.0±60.0 °C(Predicted)
- ??
- 1.266±0.06 g/cm3(Predicted)
- ?? ??
- -20°C Freezer
- ?? ?? (pKa)
- 2.44±0.20(Predicted)
- ??? ??
- Solid
- ??
- White to off-white
- CAS ??????
- 89371-37-9(CAS DataBase Reference)
??
????? C??? ??, ??, ??
??
Imidapril is a new ACE inhibitor launched in Japan as a once-daily therapy for hypertension. Its active metabolite has more potent inhibitory effects on all tissue ACES from spontaneously hypertensive rats (SHRs) and Wistar Kyoto rats (WKYs) than many other ACE inhibitors including enalapril and captopril. It has a very long duration of action. In strokeprone spontaneously hypertensive rats (SHRSP), imidapril is effective in stroke prevention at a considerably lower dose than enalapril. This stroke preventive effect has been suggested to be primarily by an indirect mechanism related to the amelioration of kidney dysfunction.??? ??
White Solid??
Angiotensin converting enzyme (ACE) inhibitor. Antihypertensive????? ?? ?? ? ???
???
N-?????????
???????????
?????
Benzyl ester
4-Phenylbutyric acid
????? ???
Midazopril hydrochloride
1-Methylpyrazole-4-ethoxycarbonyl-5-ethoxycarbonylsulfonamide
?????
??????
???
D-???
Tert-butyl ester
??? ??
(2S)-1-(3-Acetylthio-2-methyl-1-oxopropyl)-L-proline
?? ??
????? ?? ??
???( 115)?? ??
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