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NSC 663284

NSC 663284 ??? ???
?? ??:
383907-43-5
???:
NSC 663284
???(??):
NSC 663284 (DA3003-1);DA-3003-1, 10 mM in DMSO;NSC 663284 (DA3003-1), Cdc25 inhibitor;CDC25 Phosphatase Inhibitor II, NSC 663284;5,8-Quinolinedione, 6-chloro-7-[[2-(4-morpholinyl)ethyl]amino]-;CDC25 Phosphatase Inhibitor II, NSC 663284 - CAS 383907-43-5 - Calbiochem
CBNumber:
CB1504040
???:
C15H16ClN3O3
??? ??:
321.76
MOL ??:
383907-43-5.mol
MSDS ??:
SDS

NSC 663284 ??

?? ?
478.8±45.0 °C(Predicted)
??
1.41±0.1 g/cm3(Predicted)
?? ??
2-8°C
???
DMSO: 16mg/mL
??? ??
??
??? ??
??? ??
?? ?? (pKa)
6.79±0.10(Predicted)
??
???
??
Light Sensitive
???
??? ?? ?????? 2? ?? ??????. DMSO ?? ??? ??? -20°?? ?? 1?? ?? ??? ? ????.
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  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xi
?? ???? ?? 36/37/38
????? 26
WGK ?? 3
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P304+P340 ???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P405 ???? ?????.
NFPA 704
0
2 0

NSC 663284 C??? ??, ??, ??

??

CDC25 Phosphatase Inhibitor II, NSC 663284 is a competitive CDC25 inhibitor and cell cycle arresting compound.

?? ??

A cell-permable, potent, irreversible, and competitive inhibitor of the Cdc25 phosphatase family (Ki = 29 nM, 95 nM, and 89 nM for Cdc25A, Cdc25B2, and Cdc25C, respectively) with anti-proliferative properties. Displays nearly 20- and 450-fold greater selectivity over VHR and PTP1B (IC50 = 4.0 μM and >100 μM, respectively). Reported to arrest cell cycle progression, inhibit Cdk dephosphorylation, and delay tumor growth (mean IC50 = 1.5 μM in NCI-60 tumor cell panel). Also shown to block ERK dephosphorylation caused by ectopic Cdc25A expression.

???? ??

Potent, selective inhibitor of Cdc25 dual specificity phosphatases (K i values are 29, 95 and 89 nM for human Cdc25A, Cdc25B 2 and Cdc25C respectively); > 20- and > 450-fold selective over VHR and PTP1B phosphatases respectively. Arrests cells at both G 1 and G 2 /M phase and blocks cdk2 and cdk1 activation. Blocks proliferation of a range of human tumor cell lines (IC 50 = 0.2-35 μ M).

NSC 663284 ?? ?? ? ???

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NSC 663284 ?? ??

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NSC 663284 ?? ??:

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