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ISOPIMARIC ACID

ISOPIMARIC ACID ??? ???
?? ??:
5835-26-7
???:
ISOPIMARIC ACID
???(??):
isopimaricaci;Δ7,15-IsopiMaric Acid;7,15-IsopiMaradien-18-oic Acid;13β-Methyl-13-vinylpodocarp-7-en-18-oic acid;13-Methyl-17-norabieta-7,15-diene-18-oic acid;(-)-13β-Methyl-13-vinylpodocarp-7-en-15-oic Acid;1-phenanthrenecarboxylicacid,7-ethenyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahyd;7-ethenyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydro-1,4a,7-trimethyl-1-phenanthrenecarboxylicaci;(1R,4aR,4bS,7S,10aR)-1,4a,7-Trimethyl-7-vinyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydrophenanthrene-1-carboxylic acid;(1R,4aR,4bS,7S,10aR)-7-Ethenyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydro-1,4a,7-triMethyl-1-phenanthrenecarboxylic Acid
CBNumber:
CB1503654
???:
C20H30O2
??? ??:
302.45
MOL ??:
5835-26-7.mol
MSDS ??:
SDS

ISOPIMARIC ACID ??

???
160°
??
D16 -3.6° (10.4% soln in 1:1 alcohol:chloroform)
?? ?
383.47°C (rough estimate)
??
1.0434 (rough estimate)
???
1.4980 (estimate)
?? ??
-20°C
???
DMSO: ~26mg/mL
?? ?? (pKa)
4?+-.0.60(Predicted)
??? ??
??
??? ??
??? ??
??
???
???
??? ?? 1? ?? ??????. DMSO ??? -20°C?? ?? 3?? ?? ??? ? ????.
EPA
Isopimaric acid (5835-26-7)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(UN No.) UN 3077 9 / PGIII
WGK ?? 3
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H400 ????? ?? ??? ?? ????? ?? - ?? ?? 1 ?? GHS hazard pictograms P273, P391, P501
??????:
P273 ???? ???? ???.

ISOPIMARIC ACID C??? ??, ??, ??

??

A potent novel activators of large-conductance Ca2+-activated K+ channel.

?? ??

Isopimaric acid, a resin acid produced by conifer trees, is a tricyclic diterpene compound. High levels of isopimaric acid in the hepatocytes of the rainbow trout may impair calcium signalling machinery. Isopimaric acid is a potential big potassium (BK) channel opener.

Biochem/physiol Actions

Potent opener of large conductance calcium activated K+ (BK) channels.

ISOPIMARIC ACID ?? ?? ? ???

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ISOPIMARIC ACID ?? ??

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ISOPIMARIC ACID ?? ??:

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