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Sineptina

Sineptina ??? ???
?? ??:
1392-21-8
???:
Sineptina
???(??):
KITASAMYCIN;LEUCOMYCIN HYDRATE;KITASAMYCIN BASE;c637;Ayermycin;Sineptina;Syneptine;ayermicina;guitamycin;FORMACIDINE
CBNumber:
CB1338872
???:
C35H59NO13
??? ??:
701.84186
MOL ??:
1392-21-8.mol

Sineptina ??

???
128-145 °C
?? ??
Sealed in dry,2-8°C
???
???: 50mg/mL, ????? ?? ???, ?? ???
??? ??
Solid
??
???? ?????
Merck
14,5453
CAS ??????
1392-21-8
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????? 24/25
WGK ?? 1
RTECS ?? WG9400000
F ?????? 10
HS ?? 29419090
?? mouse,LD50,intraperitoneal,1758mg/kg (1758mg/kg),Drugs in Japan Vol. -, Pg. 354, 1995.
???? ?? KE-21966
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
??????:
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P501 ...? ??? / ??? ?? ???.

Sineptina C??? ??, ??, ??

??

Kitasamycin, formerly called leucomycin, was found in the culture broth of Streptoverticillium kitasatoensis by Hata et al. of the Kitasato Institute, Japan, in 1953. This was the first macrolide antibiotic with a 16-membered lactone constituent. Kitasamycin is a complex of eight leucomycin A components and is used in its base and ester forms to treat gram-positive bacterial and gram-negative coccal infections, as well as infections of Mycoplasma, Spirochaeta, and Treponema by injection or by oral topical administration.

??

Sineptina is a family of closely related macrocyclic lactone antibiotics produced by Streptomyces kitasatoensis, discovered in 1953. The complex contained over 14 components with analogues A1, A4, A5, and A13 being the most abundant analogues.Sineptina is used as an animal health product for control of Gram positive bacteria, Gram negative cocci, leptospira and mycoplasma.

Pharmaceutical Applications

A naturally occurring product of Streptomyces kitasatoensis, available in Japan for parenteral and oral use, and as acetylkitasamycin for topical application. Elsewhere it is chiefly used in veterinary medicine.

Sineptina ?? ?? ? ???

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Sineptina ?? ??

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Sineptina ?? ??:

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