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K 02288

K 02288 ??? ???
?? ??:
1431985-92-0
???:
K 02288
???(??):
CS-1877;K 02288;K 02288a;LM-3151 K02288;K 02288(K 02288a);K 02288 USP/EP/BP;K02288, 10 mM in DMSO;K02288;K 02288;K-02288;3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol;3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol
CBNumber:
CB12677546
???:
C20H20N2O4
??? ??:
352.38
MOL ??:
1431985-92-0.mol
MSDS ??:
SDS

K 02288 ??

???
201-203°C
?? ?
522.2±50.0 °C(Predicted)
??
1.232±0.06 g/cm3(Predicted)
?? ??
2-8°C
???
DMSO(?? ???), ???(?? ???)
?? ?? (pKa)
9.33±0.10(Predicted)
??? ??
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  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(UN No.) UN 2811 6.1 / PGIII
HS ?? 2933.39.9200
????(GHS): GHS hazard pictogramsGHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H301 ??? ??? ?? ?? ?? - ?? ?? 3 ?? GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H318 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 1 ?? GHS hazard pictograms P280, P305+P351+P338, P310
??????:
P280 ????/???/???/?????? ?????.
NFPA 704
0
3 0

K 02288 C??? ??, ??, ??

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Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. K02288 is a 2-aminopyridine-based inhibitor of ALK1 and ALK2 with IC50 values of 1.8 and 1.1 nM, respectively. It is less selective for ALK3, 4, 5, and 6 subtypes and the type II BMP receptor ActRIIA, demonstrating IC50 values of 34.4, 302, 321, 6.4, and 220 nM, respectively. K02288 can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC50 = 100 nM) without affecting TGF-β signaling. Furthermore, at 8-10 μM, K02288 has been used to induce the dorsalization of zebrafish embryos. Through specific inhibition of BMP signaling, this compound can be used to research stem cell biology and disease models of musculoskeletal dysplasia and cancer.

??

K02288 is a potent and selective type 1 BMP (bone morphogenetic protein) receptor inhibitor with in vitro activity against ALK-2 (activin receptor-like kinase-2) at low nanomolar concentrations. K02288 also inhibits the BMP-induced Smad pathway without affecting TGF-β signaling and induces dorsalization of zebrafish embryos.

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K02288 is a 2-aminopyridine compound.

K 02288 ?? ?? ? ???

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K 02288 ?? ??

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K 02288 ?? ??:

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