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UNC-0642

UNC-0642 ??? ???
?? ??:
1481677-78-4
???:
UNC-0642
???(??):
CS-1714;UNC0642;UNC 0642;UNC-0642;UNC-0642;UNC0642;UNC 0642;UNC0642,inhibit,Inhibitor,Histone Methyltransferase;2-(4,4-difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine;2-(4,4-Difluoropiperidin-1-yl)-6-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-4-amine;2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine;4-Quinazolinamine, 2-(4,4-difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-
CBNumber:
CB12668368
???:
C29H44F2N6O2
??? ??:
546.7
MOL ??:
1481677-78-4.mol

UNC-0642 ??

?? ?
679.2±65.0 °C(Predicted)
??
1.23±0.1 g/cm3(Predicted)
?? ??
2-8°C
???
Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
?? ?? (pKa)
10.06±0.20(Predicted)
??? ??
??
??
???? ????
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
WGK ?? 3
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
??????:
P280 ????/???/???/?????? ?????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

UNC-0642 C??? ??, ??, ??

??

UNC 0642 is an in vivo chemical probe of the lysine methyltransferases G9a and GLP which maintains high in vitro and cellular potency, low cell toxicity, and selectivity.

Biochem/physiol Actions

UNC0642 is a potent, selective inhibitor of histone methyltransferases G9a (EHMT2) and GLP (EHMT1), which catalyze the mono and dimethylation of lysine 9 of histone 3 (H3K9), and other non-histone substrates such as p53 and WIZ. UNC0642 has an in vitro IC50 <15 nM with greater than 100-fold selectivity over 13 other HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. UNC0642 has the same potency with improved PK properties relative to UNC0638, which should make it a more useful probe in an in vivo setting. For full characterization details, please visit the UNC0642 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

UNC-0642 ?? ?? ? ???

???

Methyl 2-aMino-5-Methoxy-4-(3-(pyrrolidin-1-yl)propoxy)benzoate Methyl 5-Methoxy-2-nitro-4-(3-(pyrrolidin-1-yl)propoxy)benzoate ??4-(3-???????)-5-???-2-???????? 6-Methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline-2,4-diol Methyl 4-(3-chloropropoxy)-3-Methoxybenzoate 2,4-Dichloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline 2-chloro-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine Methyl vanillate

?? ??

UNC-0642 ?? ??

???( 83)?? ??
??? ?? ??? ?? ?? ? ??
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UNC-0642 ?? ??:

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