ChemicalBook >?? ???? >(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride
(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride
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(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride ??
- ???
- 183-187°C
- ?? ?
- 529.9±60.0 °C(Predicted)
- ??
- 1.51
- ?? ??
- Refrigerator
- ???
- DMSO(?? ???), ???(?? ???)
- ??? ??
- ??
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 11.44±0.29(Predicted)
- ??
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- CAS ??????
- 188416-35-5(CAS DataBase Reference)
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(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride C??? ??, ??, ??
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Off-White Solid??
An achiral intermediate of Voriconazole (V760000).(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride ?? ?? ? ???
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(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride ?? ??
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(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride ?? ??:
??? (???????????)??????? ????? ??(I) ?????? ??? ??????? 2-???? ????? ?????????? ????(??)
2-Chloro-2',4'-difluoroacetophenone
1,2,4-Triazole
Voriconazole Impurity 53
6-(1-Bromoethyl)-4-chloro-5-fluoropyrimidine
Voriconazole
4-Chloro-6-ethyl-5-fluoropyrimidine
(trans)-6-Chloro-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
4-Ethyl-5-fluoropyrimidine