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2,4-????-N-?????-N-[2-(????????)??]???????

2,4-????-N-?????-N-[2-(????????)??]???????
2,4-????-N-?????-N-[2-(????????)??]??????? ??? ???
?? ??:
946387-07-1
???:
2,4-????-N-?????-N-[2-(????????)??]???????
???(??):
2,4-????-N-?????-N-[2-(????????)??]???????
???:
2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide
???(??):
PM-0016;RN 1734;RN-1734, TRPV4 antagonist;TRPV4 Antagonist I, RN-1734;TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 - Calbiochem;2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide;2,4-dichloro-N-propan-2-yl-N-[2-(propan-2-ylamino)ethyl]benzenesulfonamide;RN-1734 (2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide);2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulphonamide (RN-1734);2,4-Dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]benzenesulfonamide
CBNumber:
CB11529521
???:
C14H22Cl2N2O2S
??? ??:
353.31
MOL ??:
946387-07-1.mol
MSDS ??:
SDS

2,4-????-N-?????-N-[2-(????????)??]??????? ??

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2-8°C
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DMSO: >20mg/mL
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WGK ?? nwg

2,4-????-N-?????-N-[2-(????????)??]??????? C??? ??, ??, ??

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RN 1734 is a novel TRPV4 modulator.

?? ??

A cell-permeable benzenesulfonamide compound that acts as a selective TRPV4 antagonist and inhibits TRPV4 agonist 4α-PDD- (Cat. No. 524394) stimulated Ca2+ influx (IC50 = 2.3, 3.2 and 5.9 μM, respectively, in HEK293 expressing human, rat, or mouse TRPV4) without affecting the activity of three other human TRP (transient receptor potential) channels, including capsaicin- (Cat. No. 211275) activated TRPV1, camphor-activated TRPV3, and methanol-activated TRPM8 (IC50 >30 μM).

???? ??

Selective TRPV4 antagonist (IC 50 values are 2.3, 5.9 and 3.2 μ M for hTRPV4, mTRPV4 and rTRPV4 receptors respectively). Displays selectivity for over other TRP channels (IC 50 values are 2.3, >30, >30 and >100 μ M for TRPV4, TRPV3, TRPM8 and TRPV1 respectively).

2,4-????-N-?????-N-[2-(????????)??]??????? ?? ?? ? ???

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2,4-????-N-?????-N-[2-(????????)??]??????? ?? ??

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