SCIADOPITYSIN
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SCIADOPITYSIN ??
- ???
- 296-298°C
- ?? ?
- 839.6±65.0 °C(Predicted)
- ??
- 1.445±0.06 g/cm3(Predicted)
- ?? ??
- 2-8°C
- ???
- Soluble in ethanol and methan
- ??? ??
- ??
- ?? ?? (pKa)
- 6.16±0.40(Predicted)
- ??
- ???
- LogP
- 5.500 (est)
- CAS ??????
- 521-34-6
??
| ????? | 24/25 | ||
|---|---|---|---|
| HS ?? | 29329990 |
SCIADOPITYSIN C??? ??, ??, ??
??
Sciadopitysin is a biflavonoid originally isolated from G. biloba and has diverse biological activities. It reduces cytotoxicity induced by amyloid-β (1-42) (Aβ42; ) in PC12 cells (EC50 = 9.84 μM). Sciadopitysin (0.1-10 μM) decreases methylglyoxal-induced insulin secretion, production of reactive oxygen species (ROS), cardiolipin peroxidation, and cytotoxicity in RIN-m5F pancreatic β-cells. It inhibits P-glycoprotein (P-gp; IC50 = 53.42 μM) and increases cellular toxicity of paraquat and paclitaxel in MDR1-MDCKII cells. Sciadopitysin inhibits RANKL-induced mRNA expression of the osteoclast-specific genes CTSK, TRAP, and MMP-9, activation of NF-κB, and osteoclastogenesis in a mouse model of LPS-induced bone loss.??
ChEBI: A biflavonoid that is a 7, 4', 4'''-trimethyl ether derivative of amentoflavone.SCIADOPITYSIN ?? ?? ? ???
???
?? ??
SCIADOPITYSIN ?? ??
???( 152)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 |
jancyzheng@gcgreenpure.com | China | 953 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29886 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 |
scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
sales@biopurify.com | China | 3772 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28172 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39894 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 |
ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 |
1015@dideu.com | China | 4088 | 58 |
SCIADOPITYSIN ?? ??:
2-???? p-???? 4'-????-3'??????? ??????
4',7-DIMETHOXY-5-HYDROXYFLAVONE
1-(2-Hydroxy-5-methylphenyl)ethanone
2,4-Dihydroxy-3-methylbenzaldehyde
2,4,6-TRIHYDROXY-1,3-DIMETHYL BENZENE
2,2'-DIMETHOXYBIPHENYL
3-Biphenylmethanol
SCIADOPITYSIN
2-METHOXYBIPHENYL
3,3'-Dimethylbiphenyl
4-METHOXY-3-METHYLBENZYL ALCOHOL
2-PROPENAL, 3-(3-METHYLPHENYL)-,(2E)
BILOBETIN
3-Phenylbenzaldehyde
4,6-DIMETHOXYSALICYLALDEHYDE