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SCIADOPITYSIN

SCIADOPITYSIN ??? ???
?? ??:
521-34-6
???:
SCIADOPITYSIN
???(??):
Nsc 45108;SCIADOPITYSIN;Einecs 208-311-5;Sciadopitysin-RM;SCIADOPITYSIN(SH);SCIADOPITYSIN(AS) 10mg;4',4''',7-Trimethoxyamentoflavone;AMENTOFLAVONE-7,4',4'-TRIMETHYL ETHER;Amentoflavone-4',4",7-trimethyl Ether;AMENTOFLAVONE-7,4',4''-TRIMETHYL ETHER
CBNumber:
CB0273404
???:
C33H24O10
??? ??:
580.54
MOL ??:
521-34-6.mol
MSDS ??:
SDS

SCIADOPITYSIN ??

???
296-298°C
?? ?
839.6±65.0 °C(Predicted)
??
1.445±0.06 g/cm3(Predicted)
?? ??
2-8°C
???
Soluble in ethanol and methan
??? ??
??
?? ?? (pKa)
6.16±0.40(Predicted)
??
???
LogP
5.500 (est)
CAS ??????
521-34-6

??

????? 24/25
HS ?? 29329990

SCIADOPITYSIN C??? ??, ??, ??

??

Sciadopitysin is a biflavonoid originally isolated from G. biloba and has diverse biological activities. It reduces cytotoxicity induced by amyloid-β (1-42) (Aβ42; ) in PC12 cells (EC50 = 9.84 μM). Sciadopitysin (0.1-10 μM) decreases methylglyoxal-induced insulin secretion, production of reactive oxygen species (ROS), cardiolipin peroxidation, and cytotoxicity in RIN-m5F pancreatic β-cells. It inhibits P-glycoprotein (P-gp; IC50 = 53.42 μM) and increases cellular toxicity of paraquat and paclitaxel in MDR1-MDCKII cells. Sciadopitysin inhibits RANKL-induced mRNA expression of the osteoclast-specific genes CTSK, TRAP, and MMP-9, activation of NF-κB, and osteoclastogenesis in a mouse model of LPS-induced bone loss.

??

ChEBI: A biflavonoid that is a 7, 4', 4'''-trimethyl ether derivative of amentoflavone.

SCIADOPITYSIN ?? ?? ? ???

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SCIADOPITYSIN ?? ??

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