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2-????????-2'-?????

2-????????-2'-?????
2-????????-2'-????? ??? ???
?? ??:
1309371-03-6
???:
2-????????-2'-?????
???(??):
2-????????-2'-?????
???:
2-TrifluoroMethyl-2'-Methoxychalcone
???(??):
Nrf2 Activator;2-Trifluoromethyl-2'-methoxychalcone;(2E)-1-(2-Methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]-2-propen-1-one;2-Propen-1-one, 1-(2-methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]-, (2E)-
CBNumber:
CB02653893
???:
C17H13F3O2
??? ??:
306.28
MOL ??:
1309371-03-6.mol

2-????????-2'-????? ??

?? ?
395.6±42.0 °C(Predicted)
??
1.238±0.06 g/cm3(Predicted)
?? ??
Store at -20°C
???
≤11mg/ml in ethanol;5mg/ml in DMSO;14mg/ml in dimethyl formamide
??? ??
solution in acetate.
??
yellow
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(GHS): GHS hazard pictogramsGHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H225 ???? ?? ? ?? ??? ?? ?? 2 ?? GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H336 ?? ?? ???? ??? ? ?? ?????? ?? ??(1? ??);???? ?? 3 ?? P261, P271, P304+P340, P312,P403+P233, P405, P501
??????:
P210 ?·???·??·????? ????? - ?? ???.
P240 ??? ????? ?? ? ??????.
P241 ?? ??? ??[???/??/??/...]?(?) ?????.
P242 ???? ???? ?? ??? ?????
P243 ??? ?? ??? ????.
P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P271 ?? ?? ??? ? ?? ???? ?????.
P280 ????/???/???/?????? ?????.
P303+P361+P353 ??(?? ????)? ??? ??? ?? ??? ??? ????? ??? ?? ????/?????.
P304+P340 ???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P312 ???? ??? ????(??)? ??? ????.
P337+P313 ?? ?? ??? ???? ???? ??· ??? ????.
P370+P378 ?? ? ?? ?? ?? (Section 5. ??, ??? ????? ??? ???)?(?) ?????.
P403+P233 ??? ??? ? ?? ?? ??? ???? ?????.
P403+P235 ??? ? ?? ?? ???? ???? ?????.
P405 ???? ?????.
P501 ...? ??? / ??? ?? ???.
NFPA 704
3
2 0

2-????????-2'-????? C??? ??, ??, ??

??

2-Trifluoromethyl-2'-methoxychalcone is a novel chalcone derivative as potent Nrf2 activators in mice and human lung epithelial cells. 2-Trifluoromethyl-2'-methoxychalcone is a potent activator of Nrf2, both, in vitro and in mice. 4 Human bronchial epithelial cells treated with 10 μM 2-trifluoromethyl-2'-methoxychalcone showed a marked increase in the expression of the Nrf2-regulated antioxidant genes, GCLM and NQO1.

2-????????-2'-????? ?? ?? ? ???

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2-????????-2'-????? ?? ??

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