CYNARIN
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CYNARIN ??
- ?? ?
- 819.9±65.0 °C(Predicted)
- ??
- 1?+-.0.1 g/cm3(Predicted)
- ?? ??
- Keep in dark place,Sealed in dry,2-8°C
- ???
- ???5mg/mL, ??, ??~???
- ??? ??
- Solid
- ?? ?? (pKa)
- 2.50±0.50(Predicted)
- ??
- ???? ?????
- ???
- ???
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- ?? ? ???? ?? (GHS)
WGK ?? | 3 |
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????(GHS): | ||||||||||||||||||||||
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?? ?: | Warning | |||||||||||||||||||||
??·?? ??: |
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CYNARIN C??? ??, ??, ??
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1,5-Dicaffeoylquinic acid (1,5-DCQA) has been found in A. montana and is an HIV-1 integrase inhibitor and free radical scavenger. 1,5-DCQA inhibits HIV-1 integrase 3'' end processing, end joining, and disintegration with IC50 values of 0.35, 0.56, and 0.84 μg/ml, respectively. It also inhibits HIV-1 replication in MT-2 T lymphoblastoid cells with an ED50value of 2 μg/ml. 1,5-DCQA (0.25-1 μM) reduces the level of free radicals released from human polymorphonuclear (PMN) cells stimulated by N-formyl-Met-Leu-Phe (fMLP; ) in a dose-dependent manner. It also dose-dependently increases cell survival and glutathione (GSH) levels and decreases reactive oxygen species (ROS) production and lactate dehydrogenase (LDH) release in an oxygen-glucose deprivation/reperfusion assay in rat cerebral astrocytes when used at concentrations ranging from 5 to 100 μM.??
1,5-Dicaffeoylquinic Acid acts as an anti-hyperlipidemic agent. In addition, acts as a neuroprotective agent against amyloid-β toxicity in the treatement of Alzheimer’s.CYNARIN ?? ?? ? ???
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CYNARIN ?? ??
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??? | ?? | ??? | ?? | ?? ? | ?? |
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