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1-??-????-3-???????????

1-??-????-3-???????????
1-??-????-3-??????????? ??? ???
?? ??:
1690-72-8
???:
1-??-????-3-???????????
???(??):
1-??-????-3-???????????
???:
Methyl 1-methylpiperidine-3-carboxylate
???(??):
dihydroarecoline;methyln-methylnipecotate;1-methylnipecot methyl ester;1-methyl-nipecoticacimethylester;1-methylnipecoticacidmethylester;1-Methyl-3-Piperidinelarboxylate;n-methyl-3-carbomethoxypiperidine;METHYL 1-METHYLPIPERIDINE-3-CARBOXYLATE;Methyl N-methylPiperidine-3-carboxylate;1-methyl-3-piperidinecarboxylicacimethylester
CBNumber:
CB0194039
???:
C8H15NO2
??? ??:
157.21
MOL ??:
1690-72-8.mol

1-??-????-3-??????????? ??

?? ?
bp12 83-84°
??
1.013±0.06 g/cm3(Predicted)
???
nD25 1.4520
?? ??
2-8°C
?? ?? (pKa)
pKa (20°): 8.66
CAS ??????
1690-72-8(CAS DataBase Reference)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
HS ?? 2933399990
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

1-??-????-3-??????????? C??? ??, ??, ??

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Methyl 1-methylpiperidine-3-carboxylate belongs to the class of organic compounds known as piperidinecarboxylic acids. Piperidinecarboxylic acids are compounds containing a piperidine ring with a carboxylic acid group. Methyl 1-methylpiperidine-3-carboxylate is a strong basic compound (based on its pKa). It could be used to synthesize (1-methylpiperidin-3-yl)methanol. The specific steps are shown as follows: into a 500 mL round bottom flask containing a solution of methyl 1-methylpiperidine-3- carboxylate (12.0 g, 76 mmol) in tetrahydrofuran (500 mL) was added lithium aluminumhydride (4.3 g, 114 mmol) in portions at 0 °C. The reaction mixture was stirred at room temperature for 1 h. The reaction was quenched with methanol at 0 °C, and the precipitated solid was filtered through celite. The filtrate was concentrated and the crude was purified by flash chromatography eluting with methanol in dichloromethane (5-10percent) to afford (1-methylpiperidin-3-yl)methanol as a solid.

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