ChemicalBook >?? ???? >1-??-4-??-1,2,3,6-????????????
1-??-4-??-1,2,3,6-????????????
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1-??-4-??-1,2,3,6-???????????? ??
- ???
- 249.0 to 254.0 °C
- ?? ??
- Inert atmosphere,Room Temperature
- ???
- DMSO(?? ???), ???(?? ???), ?(?? ???)
- ??? ??
- ?? ??
- ??
- ???? ?????
- ???
- water: 100mg/mL
- BRN
- 3707312
- ???
- ???
- InChI
- InChI=1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H
- InChIKey
- KOWJANGMTAZWDT-UHFFFAOYSA-N
- SMILES
- C1(=CCN(C)CC1)C1C=CC=CC=1.Cl
- CAS ??????
- 23007-85-4
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
??? ?? | T | ||
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?? ???? ?? | 25-39/23/24/25-36/37/38 | ||
????? | 45-39-26 | ||
????(UN No.) | 2811 | ||
WGK ?? | 3 | ||
RTECS ?? | UT8358950 | ||
HS ?? | 2933.39.9200 | ||
?? ?? | 6.1(b) | ||
???? | III |
????(GHS): |
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1-??-4-??-1,2,3,6-???????????? C??? ??, ??, ??
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White Solid??
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride is a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.Purification Methods
Purify MPTP by recrystallisation from pKEst ~ Me2CO/isoPrOH. The free base has m 40-42o(from heptane), b 99-100o/1.3mm, 128-132o/12mm, (137-142o/0.8mm), n 25 1.5347. The hydrochloride has m 251-252o(from Me2CO/isoPrOH) [Schmidle & Mansfield J Am Chem Soc 78 425 1956, Defeudis Drug Dev Res 15 1 1988, Beilstein 20 III/IV 3240, 20/7 V 121.]?? ??
[1] Lun-Yi Zang, Hara P Misra. “Inactivation of acetylcholinesterase by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride.” Molecular and Cellular Biochemistry 254 1–2 (2003): 131–6.[2] Gregory L. Willis, Alan D. Robertson. “Recovery from experimental Parkinson’s disease in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride treated marmoset with the melatonin analogue ML-23.” Pharmacology Biochemistry and Behavior 80 1 (2005): Pages 9-26.
[3] Atsushi Fujita. “Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model.” Journal of Neuroinflammation (2018): 227.
1-??-4-??-1,2,3,6-???????????? ?? ?? ? ???
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