ChemicalBook >?? ???? >1-??-4-??-1,2,3,6-????????????
1-??-4-??-1,2,3,6-????????????
|
|
1-??-4-??-1,2,3,6-???????????? ??
- ???
- 249.0 to 254.0 °C
- ?? ??
- Inert atmosphere,Room Temperature
- ???
- DMSO(?? ???), ???(?? ???), ?(?? ???)
- ??? ??
- ?? ??
- ??
- ???? ?????
- ???
- water: 100mg/mL
- BRN
- 3707312
- ???
- ???
- InChI
- InChI=1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H
- InChIKey
- KOWJANGMTAZWDT-UHFFFAOYSA-N
- SMILES
- C1(=CCN(C)CC1)C1C=CC=CC=1.Cl
- CAS ??????
- 23007-85-4
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | T | ||
|---|---|---|---|
| ?? ???? ?? | 25-39/23/24/25-36/37/38 | ||
| ????? | 45-39-26 | ||
| ????(UN No.) | 2811 | ||
| WGK ?? | 3 | ||
| RTECS ?? | UT8358950 | ||
| HS ?? | 2933.39.9200 | ||
| ?? ?? | 6.1(b) | ||
| ???? | III |
| ????(GHS): |
 
|
|||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ?? ?: | Danger | |||||||||||||||||||||
| ??·?? ??: |
|
|||||||||||||||||||||
| ??????: |
|
1-??-4-??-1,2,3,6-???????????? C??? ??, ??, ??
??? ??
White Solid??
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride is a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.Purification Methods
Purify MPTP by recrystallisation from pKEst ~ Me2CO/isoPrOH. The free base has m 40-42o(from heptane), b 99-100o/1.3mm, 128-132o/12mm, (137-142o/0.8mm), n 25 1.5347. The hydrochloride has m 251-252o(from Me2CO/isoPrOH) [Schmidle & Mansfield J Am Chem Soc 78 425 1956, Defeudis Drug Dev Res 15 1 1988, Beilstein 20 III/IV 3240, 20/7 V 121.]?? ??
[1] Lun-Yi Zang, Hara P Misra. “Inactivation of acetylcholinesterase by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride.” Molecular and Cellular Biochemistry 254 1–2 (2003): 131–6.[2] Gregory L. Willis, Alan D. Robertson. “Recovery from experimental Parkinson’s disease in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride treated marmoset with the melatonin analogue ML-23.” Pharmacology Biochemistry and Behavior 80 1 (2005): Pages 9-26.
[3] Atsushi Fujita. “Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model.” Journal of Neuroinflammation (2018): 227.
1-??-4-??-1,2,3,6-???????????? ?? ?? ? ???
???
?? ??
1-??-4-??-1,2,3,6-???????????? ?? ??
???( 212)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Aladdin Scientific | |
tp@aladdinsci.com | United States | 57505 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12823 | 58 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33025 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29865 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49732 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 |
joe@yuhengpharm.com | CHINA | 21142 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32159 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 |
ada@ipurechemical.com | China | 10319 | 58 |