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3β,16α-ジヒドロキシ-5α-オレアナ-12-エン-28-酸

3β,16α-ジヒドロキシ-5α-オレアナ-12-エン-28-酸 化學構造式
510-30-5
CAS番號.
510-30-5
化學名:
3β,16α-ジヒドロキシ-5α-オレアナ-12-エン-28-酸
別名:
3β,16α-ジヒドロキシ-5α-オレアナ-12-エン-28-酸;3β,16α-ジヒドロキシオレアナ-12-エン-28-酸;エキノシスト酸;(4aR,5R,6aS,6bR,8aR,10S,12aR,12bR,14bS)-5,10-ジヒドロキシ-2,2,6a,6b,9,9,12a-ヘプタメチル-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-イコサヒドロピセン-4a-カルボン酸;エキノシスチン酸
英語名:
ECHINOCYSTIC ACID
英語別名:
16B1;(3B2;16u0003B1;(3u0003B2;Echinocystic;Albizziagenin;Echicystic acid;ECHINOCYSTIC ACID;Echinocystic acid-RM;ECHINOCYSTIC ACID(SH)
CBNumber:
CB8379128
化學式:
C30H48O4
分子量:
472.7
MOL File:
510-30-5.mol
MSDS File:
SDS

3β,16α-ジヒドロキシ-5α-オレアナ-12-エン-28-酸 物理性質(zhì)

融點 :
299-300°C
沸點 :
585.0±50.0 °C(Predicted)
比重(密度) :
1.14
貯蔵溫度 :
2-8°C
溶解性:
DMF:30.0(Max Conc. mg/mL);63.46(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.7(Max Conc. mM)
外見 :
powder
酸解離定數(shù)(Pka):
4.43±0.70(Predicted)
色:
White
LogP:
7.580 (est)

安全性情報

3β,16α-ジヒドロキシ-5α-オレアナ-12-エン-28-酸 価格 もっと(4)

メーカー 製品番號 製品説明 CAS番號 包裝 価格 更新時間 購入
富士フイルム和光純薬株式會社(wako) W01CHDASB-00005030 エキノシスト酸
Echinocystic Acid
510-30-5 5mg ¥29500 2024-03-01 購入
富士フイルム和光純薬株式會社(wako) W01CHDASB-00005030 エキノシスト酸
Echinocystic Acid
510-30-5 10mg ¥45900 2024-03-01 購入
富士フイルム和光純薬株式會社(wako) 49872-75
Echinocystic acid
510-30-5 20mg ¥57000 2024-07-01 購入
富士フイルム和光純薬株式會社(wako) W01CHDASB-00005030 エキノシスト酸
Echinocystic Acid
510-30-5 50mg ¥182600 2024-03-01 購入

3β,16α-ジヒドロキシ-5α-オレアナ-12-エン-28-酸 化學特性,用途語,生産方法

説明

Echinocystic acid is a triterpene that has been found in G. sinensis and has diverse biological activities. It induces nuclear translocation of the glucocorticoid receptor (GR) and reduces TNF-α-induced NF-κB signaling in HEK293 cells overexpressing GFP-GR. Echinocystic acid (12.5, 25, and 50 μM) suppresses RANKL-induced NF-κB activation, ERK phosphorylation, and osteoclastogenesis in mouse bone marrow macrophages (BMMs). It induces neurite outgrowth in Neuro2A cells in a concentration-dependent manner, an effect that can be blocked by the JNK inhibitor SP 600125 . In vivo, echinocystic acid (10 mg/kg per day) decreases escape latency in the Morris water maze and increases the length of neurite processes in the hippocampus of aged mice. Topical administration of echinocystic acid reduces expression of COX-2, inducible nitric oxide synthase (iNOS), TNF-α, and IL-1β and ear edema induced by phorbol 12-myristate 13-acetate (TPA; ) in a mouse model of dermatitis. Echinocystic acid also recovers reductions in femoral bone mineral density and trabecular thickness and number in a rat model of ovariectomy-induced osteoporosis.

使用

Echinocystic Acid is a potential entry inhibitor for the HCV infection.

3β,16α-ジヒドロキシ-5α-オレアナ-12-エン-28-酸 上流と下流の製品情報

原材料

準備製品


3β,16α-ジヒドロキシ-5α-オレアナ-12-エン-28-酸 生産企業(yè)

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510-30-5(3β,16α-ジヒドロキシ-5α-オレアナ-12-エン-28-酸)キーワード:


  • 510-30-5
  • ECHINOCYSTIC ACID
  • 3-B,16-A-DIHYDROXYOLEAN-12-EN-28-OIC ACID
  • 3BETA,16ALPHA-DIHYDROXY-OLEAN-12-EN-28-OIC ACID
  • (3beta,16alpha)-3,16-dihydroxyolean-12-en-28-oic acid
  • Echinocystic
  • ECHINOCYSTIC ACID(SH)
  • ECHINOCYSTIC ACID hplc
  • (4aR,5R,6aR,6aS,6bR,8aR,10S,12aR,14bS)-5,10-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
  • ECHINOCYSTIC ACID WITH HPLC
  • 3β,16α-Dihydroxy-5α-oleana-12-ene-28-oic acid
  • 3β,16α-Dihydroxyolean-12-en-28-oic acid
  • Echicystic acid
  • Albizziagenin
  • Echinocystic acid 510-30-5
  • Echinocystic acid, 98%, from Hedera Linn.
  • ECHINOCYSTIC ACID USP/EP/BP
  • )-3,16-dihydroxyolean-12-en-28-oic acid
  • 16B1
  • 16u0003B1
  • (3B2
  • (3u0003B2
  • Echinocystic acid (6CI)
  • Olean-12-en-28-oic acid, 3,16-dihydroxy-, (3β,16α)-
  • Echinocystic acid in methanol
  • Echinocystic acid-RM
  • 3β,16α-ジヒドロキシ-5α-オレアナ-12-エン-28-酸
  • 3β,16α-ジヒドロキシオレアナ-12-エン-28-酸
  • エキノシスト酸
  • (4aR,5R,6aS,6bR,8aR,10S,12aR,12bR,14bS)-5,10-ジヒドロキシ-2,2,6a,6b,9,9,12a-ヘプタメチル-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-イコサヒドロピセン-4a-カルボン酸
  • エキノシスチン酸
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