ナリンギン 化學(xué)特性,用途語(yǔ),生産方法
外観
白色?うすい褐色, 結(jié)晶性粉末?粉末又は小塊
定義
本品は、次の化學(xué)式で表される有機(jī)化合物である。
溶解性
水に難溶。メタノールに可溶。
用途
薬理研究用。
化粧品の成分用途
皮膚コンディショニング剤、皮膚保護(hù)剤
説明
Naringin is also called naringoside, hesperidin, and isohesperidin. It is a pale yellow
flavanone compound extracted from immature or nearly mature outer layer of C.
paradisi Macfad which belongs to Citrus grandis (L.) Osbeck. It tastes bitter and is
naturally existed in the skin and flesh of Rutaceae like grapefruit, mandarin orange,
and orange. It is also one of the active ingredients in many traditional Chinese medi cines like Rhizoma Drynariae, Immature Bitter Orange, Fructus Aurantii, and
Exocarpium Citri Grandis. The contents of naringin in different plants vary greatly
with the category and origin, and the content of naringin is high in immature fruits
. In terms of traditional Chinese medicine, the flavor of grapefruit is sweet and
sour, and the nature is cold; the flavors of its peel are sweet, pungent, and bitter, and
the nature of its peel is warm. Both the pulp and the peel of grapefruit have the bio logical function including reducing phlegm, helping digestion, relieving abdominal
distention, and fast diaphragm. And they are mainly used for the treatment of cough
with asthma, sense of suppression in the chest, coldness and pain in abdomen, dys peptic retention, and hernia.
化學(xué)的特性
beige to yellowish powder
物理的性質(zhì)
Appearance: white to light yellow crystalline powder. Solubility: soluble in metha nol, ethanol, acetone, acetic acid, dilute alkali solution, and hot water and insoluble
in nonpolar solvent like petroleum benzin, ether, benzene, and chloroform. Melting
來(lái)歴
Naringin is mainly existed in the peel of grapefruit, lime, and their varieties; it has
multiple biological activities and is widely applied in the fields of medicine, food,
and cosmetics. In the 1930s, Harvey and Rygg obtained naringin through the method
of isolation and extraction. They also established a colorimetric method for the
determination of naringin, which laid the foundation for the following researches
. Booth and other researchers conducted the systematic researches on the narin gin metabolites . In the 1960s, Hagen and other researchers established a fluores cence chromatography method for the determination naringin . In addition, the
biological activity of naringin was evaluated. It was observed to improve ascites,
experimental pulmonary edema, peritonitis, and oxygenation . At present, the
extraction methods of naringin are hot water extraction, alkali extraction, and acid
precipitation and organic solvent extraction. A series of pharmacological activity
studies have been conducted and demonstrated its various biological activities .
使用
Naringoside is a metabolite of Naringin (N378980), a major flavonoid found in grapefruit juice. It has antioxidant, lipid lowering, and anticancer activities. It is also an inhibitor of cytochrome P450 enzymes, affecting drug metabolism and thus drug absorption in humans.
定義
ChEBI: A disaccharide derivative that is (S)-naringenin substituted by a 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosi
ic linkage.
一般的な説明
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
臨床応用
It was used for the treatment of bacterial infection, calm, and cancer prevention
純化方法
This bitter principle from grape juice crystallises from water to give the hydrate with 6-8 H2O which when dried at 110o gives the dihydrate. Its solubility in H2O is 0.1% at 40o and 10% at 75o. The 2,4-dinitrophenylhydrazone crystallises from aqueous dioxane with m 246-247o [Douglass et al. J Am Chem Soc 73 4023 1951]. [Pulley & von Loesecke J Am Chem Soc 61 175 1939, Beilstein 18 III/IV 2637, 18 V 528.]
ナリンギン 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品