アシビシン
アシビシン 物理性質(zhì)
- 融點(diǎn) :
- >200°C (dec.)
- 沸點(diǎn) :
- 341.6±48.0 °C(Predicted)
- 比重(密度) :
- 1.85±0.1 g/cm3(Predicted)
- 貯蔵溫度 :
- 2-8°C
- 溶解性:
- H2O: ソリュブル10mg/mL (加溫)
- 酸解離定數(shù)(Pka):
- 2.02±0.10(Predicted)
- 外見 :
- 白い固體。
- 色:
- 白からベージュ
- 水溶解度 :
- 溫めると10mg/mlで水に溶ける
- 安定性：:
- 吸濕性
安全性情報(bào)
- リスクと安全性に関する聲明
- 危険有害性情報(bào)のコード(GHS)
| 主な危険性 |
Xn |
|
|
| Rフレーズ |
20/21/22 |
|
|
| Sフレーズ |
36 |
|
|
| RIDADR |
3172 |
|
|
| WGK Germany |
3 |
|
|
| RTECS 番號(hào) |
NY2103000 |
|
|
| 國(guó)連危険物分類 |
6.1(b) |
|
|
| 容器等級(jí) |
III |
|
|
| 絵表示（GHS） |
|
| 注意喚起語(yǔ) |
警告 |
| 危険有害性情報(bào) |
| コード |
危険有害性情報(bào) |
危険有害性クラス |
區(qū)分 |
注意喚起語(yǔ) |
シンボル |
P コード |
| H301 |
飲み込むと有毒 |
急性毒性、経口 |
3 |
危険 |
|
P264, P270, P301+P310, P321, P330,P405, P501 |
|
| 注意書き |
| P264 |
取扱い後は皮膚をよく洗うこと。 |
| P264 |
取扱い後は手や顔をよく洗うこと。 |
| P270 |
この製品を使用する時(shí)に、飲食または喫煙をしないこ と。 |
| P321 |
特別な処置が必要である（このラベルの．．． を見よ）。 |
| P405 |
施錠して保管すること。 |
|
| メーカー |
製品番號(hào) |
製品説明 |
CAS番號(hào) |
包裝 |
価格 |
更新時(shí)間 |
購(gòu)入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01LKTA0934 |
アシビシン
Acivicin |
42228-92-2 |
5mg |
￥33400 |
2024-03-01 |
購(gòu)入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01LKTA0934 |
アシビシン
Acivicin |
42228-92-2 |
10mg |
￥65300 |
2024-03-01 |
購(gòu)入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01LKTA0934 |
アシビシン
Acivicin |
42228-92-2 |
25mg |
￥147100 |
2024-03-01 |
購(gòu)入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01TRCA190150 |
Acivicin |
42228-92-2 |
1mg |
￥19200 |
2024-03-01 |
購(gòu)入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01TRCA190150 |
Acivicin |
42228-92-2 |
25mg |
￥259200 |
2024-03-01 |
購(gòu)入 |
アシビシン 化學(xué)特性,用途語(yǔ),生産方法
効能
抗悪性腫瘍薬, 代謝拮抗薬
化學(xué)的特性
Off-White Solid
使用
Azaserine and Acivicin are classical and irreversible inhibitors of γ-Glutamyltranspeptidase
定義
ChEBI: An L-alpha-amino acid that is L-alanine in which the methyl group is replaced by a (5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl group. A glutamine analogue antimetabolite, it interferes with
lutamate metabolism and several glutamate-dependent synthetic enzymes. It is obtained as a fermentation product of Streptomyces sviceus bacteria.
酵素阻害剤
This cytotoxic isoxazole and copper chelator (FW = 178.57 g/mol; CAS 42228-92-2; Source: Streptomyces sviceus), also known as L-(aS,5S)-aamino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, AT-125, and NSC165301, strongly inhibitsγ-glutamyl transpeptidase. Its clinical application in cancer treatment failed as a consequence of unacceptable toxicity, and the cause(s) of the desired and undesired biological effects have never been elucidated and only limited information about acivicin-specific targets is available. Target deconvolution by quantitative mass spectrometry (MS) has now revealed acivicin’s preference for the specific aldehyde dehydrogenase known as ALDH4A1 by binding to the catalytic site. Moreover, siRNA-mediated downregulation of ALDH4A1 results in a severe inhibition of cell growth, a finding that may explain acivicin’s cytotoxicity. Targets: Acivicin is thought to be a glutamine analogue, an assumption that is amply supported by its ability to inhibit the following enzymes that possess essential amidohydrolase activities that generate nascent ammonia: asparagine synthetase; carbamoyl-phosphate synthetase; anthranilate synthase; glutamate synthase; CTP symthetase; amidophospho-ribosyltransferase; glutamin(asparagin)ase, or glutaminase-asparaginase; GMP synthase, glutamine-dependent; phosphoribosyl-formylglycinamidine synthetase (formylglycinamidine ribonucleotide synthetase; thiol oxidase; γ-glutamyl hydrolase; imidazole-glycerol phosphate synthetase.
アシビシン 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品
アシビシン 生産企業(yè)
Global( 91)Suppliers
42228-92-2(アシビシン)キーワード:
- 42228-92-2
- (alpha-s,5s)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleaceticacid
- (s-(r*,r*))-4,5-dihydro-alpha-amino-3-chloro-5-isoxazoleaceticacid
- 4,5-dihydro-alpha-amino-3-chloro-,(s-(r*,r*))-5-isoxazoleaceticaci
- acivicine
- antibioticat125
- nsc-163501
- AT-125
- ALPHA-AMINO-3-CHLORO-4,5-DIHYDRO-5-ISOXAZOLEACETIC ACID
- α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
- AMINO-3-CHLORO-4,5-DIHYDROXY-5-ISOXAZOLEACETICACID
- DIHYDROXY-5-ISOXAZOLEACETICACID
- (5S,αS)-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
- Antibiotic U-42126
- U-42126
- (αS,5S)-
- (a-S, 5S)-a-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
- AcivicinAcivicin
- ACIVICIN
- (2S)-2-Amino-2-[(5S)-3-chloro-4,5-dihydroisoxazol-5-Yl]acetic acid
- 5-Isoxazoleacetic acid, α-amino-3-chloro-4,5-dihydro-, (αS,5S)-
- 5-Isoxazoleacetic acid,a-amino-3-chloro-4,5-dihydro-, (aS,5S)-
- (S)-2-Amino-2-((S)-3-chloro-4,5-dihydroisoxazol-5-yl)acetic acid
- (2S)-2-amino-2-[(5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]acetic acid
- 抗生物質(zhì)U-42126
- (5S,αS)-α-アミノ-3-クロロ-4,5-ジヒドロ-5-イソオキサゾール酢酸
- アシビシン
- (αS,5S)-α-アミノ-3-クロロ-4,5-ジヒドロ-5-イソオキサゾール酢酸
- (S)-α-アミノ-α-[[(S)-3-クロロ-4,5-ジヒドロイソオキサゾール]-5-イル]酢酸
- (2S)-2-アミノ-2-[(5S)-3-クロロ-4,5-ジヒドロ-1,2-オキサゾール-5-イル]酢酸
- 抗腫瘍抗生物質(zhì)