3β,21-ジヒドロキシ-5α-プレグナン-20-オン 価格 もっと(2)

メーカー	製品番號	製品説明	CAS番號	包裝	価格	更新時間	購入
Sigma-Aldrich Japan	P2016	3α,21-ジヒドロキシ-5α-プレグナン-20-オン ≥95% 3α,21-Dihydroxy-5α-pregnan-20-one ≥95%	567-02-2	5mg	￥49400	2024-03-01	購入
Sigma-Aldrich Japan	P2016	3α,21-ジヒドロキシ-5α-プレグナン-20-オン ≥95% 3α,21-Dihydroxy-5α-pregnan-20-one ≥95%	567-02-2	10mg	￥77600	2024-03-01	購入

3β,21-ジヒドロキシ-5α-プレグナン-20-オン 化學(xué)特性,用途語,生産方法

使用

3α,21-Dihydroxy-5α-pregnan-20-one (THDOC) has been used:

• as an γ-aminobutyric acid type A receptor (γ-GABAA) agonist in voltage-clamp measurements studies in Xenopus oocytes
• to test its effect on the spike-wave discharges (SWD) finasteride-treated rats
• in electrophysiological studies with dentate granule cells (DGCs) post controlled cortical impact (CCI) -induced brain injury

一般的な説明

3α21-Dihydroxy-5α-pregnan-20-one (THDOC) is a neurosteroid. It is synthesized in a two-step process from deoxycorticosterone (DOC) via 5α-dihydrodeoxycorticosterone (DHDOC) intermediate with enzymes 5α-reductase and 3α-hydroxysteroid oxidoreductase catalyzing these steps respectively.

Biochem/physiol Actions

3α,21-Dihydroxy-5α-pregnan-20-one (THDOC) is a positive allosteric modulator of the γ-aminobutyric acid A receptor (GABAA). By modulating GABAA receptor, THDOC allows sustained hyperpolarization and an increase in chloride influx and membrane conductance in neurons. THDOC, thus modulates neuronal excitability. It possesses anxiolytic, anticonvulsant and sedative properties. The levels of THDOC show variation in different physiological states. A low THDOC level in the mensural phase is speculated to play a role in the pathogenesis of catamenial epilepsy (CE) in women. However, elevated levels are reported in depression. THDOC may have an indirect role in the hypothalamic-pituitary–adrenal (HPA) axis activation during acute stress.

3β,21-ジヒドロキシ-5α-プレグナン-20-オン 上流と下流の製品情報

原材料

準(zhǔn)備製品

3β,21-ジヒドロキシ-5α-プレグナン-20-オン 生産企業(yè)

名前	電話番號	電子メール	國籍	製品カタログ	優(yōu)位度
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 15319487004	1015@dideu.com	China	3939	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32159	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30231	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Aladdin Scientific		tp@aladdinsci.com	United States	52924	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	94657	76
Wuxi Zhongkun Biochemical Technology Co., Ltd.	0510-85629785 18013409632	sales@reading-chemicals.com	China	15178	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80
BOC Sciences	16314854226	info@bocsci.com	United States	9923	65

567-02-2(3β,21-ジヒドロキシ-5α-プレグナン-20-オン)キーワード:

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• 567-02-2
• ALLOPREGNANE-3ALPHA,21-DIOL-20-ONE
• ALLOTETRADEOXYCORTICOSTERONE
• ALLOTETRAHYDROCORTEXONE
• ALLOTETRAHYDRODEOXYCORTICOSTERONE
• ALLOTETRAHYDRODESOXYCORTICOSTERONE
• ALLOTETRAHYDRO DOC
• ALLOTETRAHYDRO SUBSTANCE 'Q'
• ALLO TH DOC
• 5-ALPHA-PREGNAN-3-ALPHA, 21-DIOL-20-ONE
• 5ALPHA-PREGNANE-3ALPHA,21-DIOL-20-ONE
• 3ALPHA,21-DIHYDROXY-5ALPHA-PREGNAN-20-ONE
• 21-HYDROXYALLOPREGNANOLONE
• 5A-pregnane-3A,21-diol-20-one
• 5alpha-Pregnan-3alpha,21-diol-20-one-17,21,21-D3
• 3α,21-dihydroxy-5α-pregnan-20-one
• 5α-Pregnane-3α,21-diol-20-one
• 5α-Pregnan-3α,21-diol-20-one-17,21,21-D3
• 21-Hydroxyallopregnanolone, 5α-Pregnane-3α,21-diol-20-one, 5α-THDOC, Allopregnane-3α,21-diol-20-one, Allotetrahydrodeoxycorticosterone
• 3β,5α-Tetrahydrodeoxycorticosterone
• TDOC
• 5α-THDOC
• Allopregnane-3α,21-diol-20-one
• Allotetrahydrodeoxycorticosterone (Solution)
• 1-HYDROXYALLOPREGNANOLONE
• Pregnan-20-one, 3,21-dihydroxy-, (3α,5α)-
• "3α,21-Dihydroxy-5a-pregnan-20-one"
• 5alpha-THDOC
• 3α,21Dihydroxy5αpregnan20one,3α,21 Dihydroxy 5α pregnan 20 one
• 3α,5α-THDOC
• 5α-PREGNAN-3α, 21-DIOL-20-ONE
• 3α,21-ジヒドロキシ-5α-プレグナン-20-オン
• 3α,5α-テトラヒドロデオキシコルチコステロン
• 3β,5α-テトラヒドロデオキシコルチコステロン
• アロテトラヒドロデオキシコルチコステロン
• 3β,21-ジヒドロキシ-5α-プレグナン-20-オン
• 1-(3β-ヒドロキシ-5α-アンドロスタン-17β-イル)-2-ヒドロキシエタノン
• 1-[(1S,3aS,3bR,5aS,7R,9aS,9bS,11aS)-7-ヒドロキシ-9a,11a-ジメチル-ヘキサデカヒドロ-1H-シクロペンタ[a]フェナントレン-1-イル]-2-ヒドロキシエタン-1-オン
• 1-[(1S,3aS,3bR,5aS,7S,9aS,9bS,11aS)-7-ヒドロキシ-9a,11a-ジメチル-ヘキサデカヒドロ-1H-シクロペンタ[a]フェナントレン-1-イル]-2-ヒドロキシエタン-1-オン