2,2-ビス(4-グリシジルオキシフェニル)プロパン 化學(xué)特性,用途語(yǔ),生産方法
外観
無(wú)色～ほとんど無(wú)色透明液體
用途
食品包裝用エポキシ樹(shù)脂?ポリカーボネート樹(shù)脂の原料
説明
Most epoxy resins result from polymerization of
bisphenol A diglycidyl ether (BADGE). Delayed hypersensitivity
is caused by the low-molecular-weight
monomer BADGE (MW 340 g/mol), the dimer having
a much lower sensitization power. This allergen caused
contact dermatitis in six workers in a plant producing
printed circuits boards made of copper sheets and
fiberglass fabric impregnated with a brominated epoxy
resin. It can also be contained in adhesives.
化學(xué)的特性
Diglycidyl ether of bisphenol A is a colorless to light amber liquid. Slight epoxy odor.
使用
Bisphenol A derivative. A PPARγ antagonist; exhibits estrogenic activity; An inhibitor of PPARγ and suppressor of TNFα.
調(diào)製方法
The synthesis of the basic epoxy resin molecule involves the
reaction of epichlorohydrin with bisphenol A, the latter
requiring two basic intermediates for synthesis, acetone
and phenol. Theoretically, the production of the bisphenol
A diglycidyl ether requires 2 mol of epichlorohydrin for each
mole of the phenol.
Epoxy resins of higher molecular weight are obtained by
reducing the epichlorohydrin/bisphenol A ratio. This reaction
involves consumption of the initial epoxy groups in the
epichlorohydrin and of some of the groups formed by
dehydrohalogenation.
一般的な説明
Odorless yellowish brown liquid. Sinks in water.
空気と水の反応
Oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick 1979 p.151-154, 164]. Insoluble in water.
反応プロフィール
Epoxides, such as BISPHENOL A DIGLYCIDYL ETHER RESIN, are highly reactive. They polymerize in the presence of catalysts or when heated. These polymerization reactions can be violent. Compounds in this group react with acids, bases, and oxidizing and reducing agents. They react, possibly violently with water in the presence of acid and other catalysts.
健康ハザード
Contact with liquid irritates eyes. Prolonged or repeated contact with skin causes irritation and dermatitis.
火災(zāi)危険
BISPHENOL A DIGLYCIDYL ETHER RESIN is probably combustible.
生物活性
PPAR γ pure antagonist with micromolar affinity in 3T3-L1 and 3T3-F442A preadipocyte cells; selective over PPAR δ and PPAR α . Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPAR γ . Acts as a PPAR γ agonist in an ECV304 cell line. Also produces PPARg-independent apoptosis of tumor cells via several mechanisms. Active in vivo .
接觸アレルゲン
Most epoxy resins result from polymerization of bisphenol
A diglycidyl ether (BADGE). Delayed hypersensitivity
is caused by the low-molecular-weight
monomer BADGE (Molecular Weight 340 g/mol),
the dimer having much a lower sensitization power.
This allergen caused contact dermatitis in six workers
in a plant producing printed circuits boards made
of copper sheets and fiber glass fabric impregnated
with a brominated epoxy resin. It can be contained in
adhesives.
職業(yè)ばく露
Diglycidyl ether of bisphenol A is used as a basic active ingredient of epoxy resins.
発がん性
In summary, a number of carcinogenicity studies involving
the topical application of pure BADGE as well as EPON
Resin 828 and other commercial BADGE-based resins have
been carried out in experimental animals.Viewing the studies
as a whole, the weight of evidence does not show that
BADGE or BADGE-based epoxy resins are carcinogenic.
不和合性
Easily oxidized in air; presumed to form unstable and explosive peroxides in storage. Incompatible with strong acids; strong oxidizers.
廃棄物の処理
Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
2,2-ビス(4-グリシジルオキシフェニル)プロパン 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品