3-(Acetylamino)-4-hydroxybenzoic acid synthesis
- Product Name:3-(Acetylamino)-4-hydroxybenzoic acid
- CAS Number:91004-38-5
- Molecular formula:C9H9NO4
- Molecular Weight:195.17
108-24-7
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$14.00/250ML
1571-72-8
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$8.00/1g
91004-38-5
12 suppliers
$88.00/250 mg
Yield: 96%
Reaction Conditions:
with acetic acid at 60; for 2 h;
Steps:
1 Compound synthesis of the specific process
Compound I (1 mol) was added to the reaction flask,Dissolved in acetic acid (1L) Stirring to dissolve,Warmed to 60 ° C,Acetic anhydride (1.5 mol) was added dropwise to the solution,Dropping is completed,Control the reaction temperature 60 2h.HPLC detection,Raw material fully reacted.The reaction solution was cooled to room temperature,Pour into the water, stir 1h,A solid precipitation, suction filtration, solid inDrying in vacuo at 40 ° C gave Compound II (0.96 mol) in 96% yield.
References:
Jiangsu Furui Bio-pharmaceutical Co., Ltd.;Chen Benshun CN107325049, 2017, A Location in patent:Paragraph 0035-0036
126360-59-6
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91004-38-5
12 suppliers
$88.00/250 mg
1571-72-8
263 suppliers
$8.00/1g
91004-38-5
12 suppliers
$88.00/250 mg
536-25-4
192 suppliers
$11.00/250mg
91004-38-5
12 suppliers
$88.00/250 mg