ラウリン酸 化學(xué)特性,用途語(yǔ),生産方法
外観
白色の粒狀
定義
本品は、次の化學(xué)式で表される脂肪酸である。
定義
ラウリン酸は，飽和脂肪酸の一つ。ドデカン酸ともよばれる。グリセリドの一種であるラウリンとして、やし油、ゲッケイジュの果肉油などの植物油中に含まれている。ラウリンの名はゲッケイジュの學(xué)名Laurus nobilis L.に由來(lái)する。やし油の混合脂肪酸をエステル化し、減圧下で分留したのち、けん化すると得られる。白色針狀結(jié)晶で、水には溶けないが、エーテル、ベンゼンなどの有機(jī)溶剤にはよく溶ける。洗剤や界面活性剤に用いられるラウリルアルコールの原料となる。
溶解性
水に不溶。エタノール, アセトンに可溶。ベンゼン, エーテルに易溶。エタノール及びアセトンに溶け、水にほとんど溶けない。
解説
dodecanoic acid．C12H24O2(200.31)．CH3(CH2)10COOH．グリセリドとしてやし油や月桂樹油など，種々の植物油中に含まれている．やし油の混合脂肪酸をエステル化し，減圧下で分留したのち，けん化すると得られる．無(wú)色の針狀晶．融點(diǎn)44 ℃，沸點(diǎn)225 ℃(13.3 kPa)，160～165 ℃(2.66 kPa)．d540.869．n82D1.4183．水に不溶，エタノールに可溶，ベンゼン，エーテルに易溶．わずかであるが刺激性を有する．界面活性剤の原料に用いられる．[CAS 143-07-7]
森北出版「化學(xué)辭典（第2版）
用途
可塑剤、安定剤、香料、化粧品、油剤?jiān)?
用途
カルボン酸分析標(biāo)準(zhǔn)、有機(jī)合成原料。
用途
合成原料及び添加剤(醫(yī)薬品、化粧品、界面活性剤)。
用途
有機(jī)合成原料(ラウリルアルコール、エステル、香料等)、機(jī)器分析等の標(biāo)準(zhǔn)。
化粧品の成分用途
洗浄剤、香料
効能
界面活性剤
説明
Lauric acid, also known as dodecanoic acid, is a saturated fatty acid with a 12-carbon atom chain, thus falling into the medium chain fatty acids, is a white crystalline carboxylic acid with a faint odor of bay oil or soap. It has been found at high levels in coconut oil. Lauric acid induces the activation of NF-κB and the expression of COX-2, inducible nitric oxide synthase (iNOS), and IL-1α in RAW 264.7 cells when used at a concentration of 25 μM.
物理的性質(zhì)
Lauric acid occurs as a white crystalline powder with a slight odor of bay oil or a fatty odor. It is a common constituent of most diets; large doses may produce gastrointestinal upset.
化學(xué)的特性
Like many other fatty acids, lauric acid is inexpensive, has a long shelf-life, and is non-toxic and safe to handle. It is mainly used for the production of soaps and cosmetics. For these purposes, lauric acid is neutralized with sodium hydroxide to give sodium laurate, which is a soap. Most commonly, sodium laurate is obtained by saponification of various oils, such as coconut oil. These precursors give mixtures of sodium laurate and other soaps.
天然物の起源
Lauric acid, as a component of triglycerides, comprises about half of the fatty acid content in coconut oil, laurel oil, and in palm kernel oil (not to be confused with palm oil) , Otherwise it is relatively uncommon. It is also found in human breast milk ( 6.2 % of total fat), cow's milk (2.9%), and goat's milk (3.1 %).
使用
Given its foaming properties, the derivatives of lauric acid (h-dodecanoic acid) are widely used as a base in the manufacture of soaps, detergents, and lauryl alcohol. Lauric acid is a common constituent of vegetable fats, especially coconut oil and laurel oil. It may have a synergistic effect in a formula to help fight against mircoorganisms. It is a mild irritant but not a sensitizer, and some sources cite it as comedogenic.
定義
ChEBI: Lauric acid is a straight-chain, twelve-carbon medium-chain saturated fatty acid with strong bactericidal properties; the main fatty acid in coconut oil and palm kernel oil. It has a role as a plant metabolite, an antibacterial agent and an algal metabolite. It is a straight-chain saturated fatty acid and a medium-chain fatty acid. It is a conjugate acid of a dodecanoate. It derives from a hydride of a dodecane.
調(diào)製方法
Lauric acid is a fatty carboxylic acid isolated from vegetable and
animal fats or oils. For example, coconut oil and palm kernel oil
both contain high proportions of lauric acid. Isolation from natural
fats and oils involves hydrolysis, separation of the fatty acids,
hydrogenation to convert unsaturated fatty acids to saturated acids,
and finally distillation of the specific fatty acid of interest.
一般的な説明
White solid with a slight odor of bay oil.
空気と水の反応
Insoluble in water.
健康ハザード
May be harmful by inhalation, ingestion or skin absorption. Vapor or mist is irritating to eyes, mucous membrane and upper respiratory tract. Causes eye and skin irritation.
火災(zāi)危険
Behavior in Fire: May cause dust explosion.
応用例（製薬）
pharmaceutical applications it has also been examined for use as an
enhancer for topical penetration and transdermal absorption,
rectal absorption, buccal delivery,(14) and intestinal absorption.
It is also useful for stabilizing oil-in-water emulsions.
Lauric acid has also been evaluated for use in aerosol formulations.
安全性
Lauric acid is widely used in cosmetic preparations, in the
manufacture of food-grade additives, and in pharmaceutical
formulations. General exposure to lauric acid occurs through the
consumption of food and through dermal contact with cosmetics,
soaps, and detergent products. Lauric acid is toxic when
administered intravenously.
Occupational exposure may cause local irritation of eyes, nose,
throat, and respiratory tract, although lauric acid is considered
safe and nonirritating for use in cosmetics. No toxicological
effects were observed when lauric acid was administered to rats at
35% of the diet for 2 years. Acute exposure tests in rabbits
indicate mild irritation. After subcutaneous injection into mice,
lauric acid was shown to be noncarcinogenic.
LD50 (mouse, IV): 0.13 g/kg
LD50 (rat, oral): 12 g/kg
発がん性
Lauric acid was not carcinogenic
in the BALB/c:CFW mouse after repeated subcutaneous
injections. Lauric acid applied twice weekly for 20
weeks did not promote tumors in mice initiated with 9,10-
dimethyl-1,2-benzanthracene. After more extended
application (daily, 6 days/week, for 31 weeks), lauric acid
caused an increase in skin papillomas, but no histologically
malignant tumors were found. Lauric acid was not
carcinogenic in rats after exposure in the diet to 35% lauric
acid for 2 years.
貯蔵
Lauric acid is stable at normal temperatures and should be stored in
a cool, dry place. Avoid sources of ignition and contact with
incompatible materials.
純化方法
Distil the acid in a vacuum. Also crystallise it from absolute EtOH, or from acetone at -25o. Alternatively, purify it via its methyl ester (b 140.0o/15mm), as described for capric acid. It has also been purified by zone melting. [cf Beilstein 1 III 2913.]
不和合性
Lauric acid is incompatible with strong bases, reducing agents, and
oxidizing agents.
規(guī)制狀況(Regulatory Status)
GRAS listed. Lauric acid is listed as a food additive in the EAFUS list
compiled by the FDA. Reported in the EPA TSCA Inventory.
ラウリン酸 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品