18,21-ジヒドロキシプレグナ-4-エン-3,20-ジオン 価格

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18,21-ジヒドロキシプレグナ-4-エン-3,20-ジオン 化學特性,用途語,生産方法

説明

18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland. Its biosynthesis is regulated by adrenocorticotropic hormone (ACTH; ) as well as angiotensin II , which increases 18-OH-DOC production in isolated human adrenal glomerulosa cells. 18-OH-DOC can be formed via conversion of 11-deoxy corticosterone (DOC; ) in human SK-MEL188 melanoma cells. 18-OH-DOC is an intermediate in the metabolism of progesterone and can be converted to aldosterone by the capsular portion of rat adrenal glands. Continuous infusion of 18-OH-DOC (200 μg/rat per day) increases systolic blood pressure in uninephrectomized saline-drinking rats. Plasma levels of 18-OH-DOC are elevated in a db/db mouse model of type 2 diabetes.

使用

11-Deoxy-18-hydroxycorticosterone is an analog of Corticosterone (C695700); a glucocorticoid and intermediate in the biosynthesis of Aldosterone (A514700) which is an adrenocortical steroid isolated from the adrenal cortex.

純化方法

Recrystallise 18-hydroxy-11-deoxycorticosterone from Et2O/Me2CO to give crystals m 200-205o. When it is recrystallised from M2CO, it has m 191-195o. It has UV with max at 240nm. The 21-O-acetoxy-18-hydroxy derivative has m 158-159o (from Et2O/*C6H6), and the 21-O-acetoxy-18,20-epoxy derivative has m 149-154o (from Et2O). [Kahnt et al. Helv Chim Acta 38 1237 1955; Pappo J Am Chem Soc 81 1010 1959.]

18,21-ジヒドロキシプレグナ-4-エン-3,20-ジオン 上流と下流の製品情報

原材料

準備製品

18,21-ジヒドロキシプレグナ-4-エン-3,20-ジオン 生産企業(yè)

名前	電話番號	電子メール	國籍	製品カタログ	優(yōu)位度
DAYANG CHEM (HANGZHOU) CO.,LTD	+86-88938639 +86-17705817739	info@dycnchem.com	China	53900	58
BOC Sciences	--	info@bocsci.com	USA	0	65
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44918	58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd	029-029-81148696 18161915376	1040@dideu.com	China	9799	58
LGC Science (Shanghai) Ltd.	17717235263	cindy.yang@lgcgroup.com	China	17730	58
Shanghai Saikerui Biotechnology Co. , Ltd.	021-58000709 15900491054	info@scrbio.com	China	9522	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11973	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19949	58
SHANGHAI ZZBIO CO., LTD.	15102117276 19921389125	tech@zzbioco.com	China	12064	58

379-68-0(18,21-ジヒドロキシプレグナ-4-エン-3,20-ジオン)キーワード:

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• 379-68-0
• (8R,9S,10R,13R,14S,17S)-17-(2-hydroxyethanoyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
• (8R,9S,10R,13R,14S,17S)-17-glycoloyl-10-methyl-13-methylol-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
• 11-DEOXY-18-HYDROXYCORTICOSTERONE
• 18-HYDROXY-11-DEOXYCORTICOSTERONE
• 18-HYDROXYDEOXYCORTICOSTERONE
• 18-HYDROXY DOC
• 18,20-EPOXY-20,21-DIHYDROXY-4-PREGNEN-3-ONE
• 18,21-DIHYDROXY-4-PREGNENE-3,20-DIONE
• 4-PREGNENE-18,21-DIOL-3,20-DIONE
• 4-PREGNEN-18,21-DIOL-3,20-DIONE
• 18,21-dihydroxypregn-4-ene-3,20-dione
• 11-Deoxy-18-hydroxycorticosterone, 18,20-Epoxy-20,21-dihydroxy-4-pregnen-3-one, 18,21-Dihydroxy-4-pregnene-3,20-dione
• 18-Hydroxy-21-hydroxypregna-4-ene-3,20-dione
• (8R,9S,10R,13R,14S,17S)-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
• Pregn-4-ene-3,20-dione, 18,21-dihydroxy-
• 18,20-EPOXY-20,21-DIHYDROXYPREGN-4-EN-3-ONE
• 18-ヒドロキシ-21-ヒドロキシプレグナ-4-エン-3,20-ジオン
• 18-ヒドロキシデオキシコルチコステロン
• 18-ヒドロキシ-11-デオキシコルチコステロン
• 18,21-ジヒドロキシプレグナ-4-エン-3,20-ジオン
• 11-デオキシ-18-ヒドロキシコルチコステロン
• (1S,3aS,3bR,9aR,9bS,11aR)-1-(2-ヒドロキシアセチル)-11a-(ヒドロキシメチル)-9a-メチル-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-シクロペンタ[a]フェナントレン-7-オン
• 18-ヒドロキシデスオキシコルチコステロン