Piriprost
- CAS No.
- 79672-88-1
- Chemical Name:
- Piriprost
- Synonyms
- U-60257;Piriprost;Piriprostium;Unii-R802o5nilk;Piriprostium [latin];(4R)-1,4,5,6-Tetrahydro-5α-hydroxy-4β-[(E,S)-3-hydroxy-1-octenyl]-1-phenylcyclopenta[b]pyrrole-2-pentanoic acid;(4R)-1,4,5,6-Tetrahydro-5α-hydroxy-4β-[(1E,3S)-3-hydroxy-1-octenyl]-1-phenylcyclopenta[b]pyrrole-2-pentanoic acid;Cyclopenta(B)pyrrole-2-pentanoic acid, 1,4,5,6-tetrahydro-5-hydroxy-4-((1E,3S)-3-hydroxy-1-octenyl)-1-phenyl-, (4R,5R)-;Cyclopenta(B)pyrrole-2-pentanoic acid, 1,4,5,6-tetrahydro-5-hydroxy-4-(3-hydroxy-1-octenyl)-1-phenyl-, (4R-(4alpha(1E,3S*),5beta))-
- CBNumber:
- CB91179531
- Molecular Formula:
- C26H35NO4
- Molecular Weight:
- 425.565
- MDL Number:
- MFCD00864807
- MOL File:
- 79672-88-1.mol
FDA UNII | R802O5NILK |
---|
Piriprost Chemical Properties,Uses,Production
Uses
Anti-asthmatic.
Enzyme inhibitor
This lipoxygenase-inhibiting pyrrole analogue of prostacyclin (FWpotassium salt = 463.66 g/mol; CAS 79672-88-1), also known as U60257B and 6,9- deepoxy-6,9-(phenylimino)-D6,8-prostaglandin I1, [4R-[4a(1E,3S*),5b]]- 1,4,5,6-tetrahydro-5-hydroxy-4-(3-hydroxy-1-octenyl)-1-phenylcyclopenta[ b]pyrrole-2-pentanoate, inhibits leukotriene C and D formation.1-5 Piriprost also inhibits the release of histamine and leukotrienes from isolated porcine lung cells.6 Note that both priprost and its methyl ester (U-56467) inhibit leukotriene biosynthesis: ID50 = 4.6 and 0.31 μM, respectively. Target(s): glutathione S-transferase; and 5- lipoxygenase, or arachidonate 5-lipoxygenase.
Piriprost Preparation Products And Raw materials
Raw materials
Preparation Products
Piriprost Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19905 | 58 |
TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19965 | 58 |
Supplier | Advantage |
---|---|
TargetMol Chemicals Inc. | 58 |
TargetMol Chemicals Inc. | 58 |