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ChemicalBook >> CAS DataBase List >>H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH

H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH

CAS No.
117399-93-6
Chemical Name:
H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH
Synonyms
et-3;EDN3;HSCR4;human,rat;ET-3, HUMAN;ENDOTHELIN-3;CAS:117399-93-6;Rat endothelin-3;ET-3 (HUMAN, RAT);Endothelin 3【rat】
CBNumber:
CB7181630
Molecular Formula:
C121H168N26O33S4
Molecular Weight:
2643.04
MDL Number:
MFCD00076378
MOL File:
117399-93-6.mol
Last updated:2025-04-17 18:22:24

H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH Properties

Density 1.285±0.06 g/cm3(Predicted)
storage temp. −20°C
solubility 5% acetic acid: 0.5mg/mL
form powder
color white
biological source rabbit
Water Solubility Soluble to 1 mg/ml in water
FDA UNII 0066WLJ02E
UNSPSC Code 12352203
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H300+H330
Precautionary statements  P301+P310+P330-P304+P340+P310
Safety Statements  22
WGK Germany  3
F  3-10

H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich E9137 Endothelin 3 human, rat ≥97%(HPLC),powder 117399-93-6 10μg $127 2024-03-01 Buy
Sigma-Aldrich E9137 Endothelin 3 human, rat ≥97%(HPLC),powder 117399-93-6 50μg $226.2 2024-03-01 Buy
Sigma-Aldrich E9137 Endothelin 3 human, rat ≥97%(HPLC),powder 117399-93-6 0.1mg $679 2024-03-01 Buy
Sigma-Aldrich 05-23-3801 Endothelin 3, Human and Rat Attenuates thrombin-evoked aggregation of human platelets. 117399-93-6 0.5MG $509 2024-03-01 Buy
Sigma-Aldrich 05-23-3801 Endothelin 3, Human and Rat - CAS 117399-93-6 - Calbiochem Attenuates thrombin-evoked aggregation of human platelets. 117399-93-6 .5mg $487 2023-01-07 Buy
Product number Packaging Price Buy
E9137 10μg $127 Buy
E9137 50μg $226.2 Buy
E9137 0.1mg $679 Buy
05-23-3801 0.5MG $509 Buy
05-23-3801 .5mg $487 Buy

H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH Chemical Properties,Uses,Production

Uses

Endothelin 3 human, rat has been used for culturing neural tube explant culture, and the pharmacological study of endothelin receptors.

General Description

Endothelin 3 (ET3) belongs to endothelin peptide family, which includes three members, ET-1, -2 and -3. These are 21-amino acid peptides, which are synthesized as precursors. They are converted to biologically active peptides, after being cleaved by proteases. There are two endothelin receptors called ETRA and ETRB, and ET3 binds to ETRB. It is localized to human intestine and colon.

Biochem/physiol Actions

Endothelin 3 (ET3) is a vasoconstrictor that acts in a paracrine and autocrine manner, and in intestinal lamina propria causes the degranulation of mast cells. It results in the release of ions from intestinal epithelial cells. In acute and chronic intestinal inflammation, it is overexpressed. It is also up-regulated in colon carcinoma, where it supports cell proliferation and survival. It might be involved in colon homeostasis, and is essential for the survival and proliferation of goblet cells. In mice, it is essential for the development of pigment cells derived from neural crest (NC). Its expression is de-regulated in metastatic melanoma.

in vivo

Endothelin-3 at low concentrations may attenuate inflammatory responses via ETB2 activation and NO production. Endothelin-3, which acts mainly on ETB, at low concentrations specifically inhibited platelet-activating factor (PAF)-induced paw oedema, whereas neither ET-1 nor Endothelin-2, both of which act on ETA and ETB, showed inhibitory activity. The inhibition by ET-1 and Endothelin-3 (each 0.5 pmol/paw) in the presence of BQ-123 (66.4 ± 6.7 % and 65.4 ± 22.6 %, respectively), is comparable to that by Endothelin-3 (0.5 pmol/paw) alone (65.4 ± 10.9 %), whereas neither ET-1 nor Endothelin-3 in the presence of BQ-788 showed inhibitory activity[3].

storage

Store at -20°C

H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH Preparation Products And Raw materials

Raw materials

Preparation Products

H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH Suppliers

Global( 124)Suppliers
Supplier Tel Email Country ProdList Advantage
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10406 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Cellmano Biotech Limited 		0551-65326643 18156095617 info@cellmano.com China 995 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29808 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22855 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Hangzhou Go Top Peptide Biotech 		0571-88211921 sales1@gotopbio.com CHINA 2609 58
Alfa Chemistry 		Info@alfa-chemistry.com United States 24072 58
Chengdu Youngshe Chemical Co., Ltd. 		+8618108235634 Cecilia@youngshechem.com China 2345 58

View Lastest Price from H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH pictures 2020-02-13 H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH
117399-93-6
 US $7.00 / KG 1KG 99% 100KG Career Henan Chemical Co
H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH pictures 2020-02-13 H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH
117399-93-6
 US $7.00 / KG 1KG 99% 100KG Career Henan Chemical Co
ENDOTHELIN-III, HUMAN, RAT ENDOTHELIN-3 ENDOTHELIN-3, HUMAN ENDOTHELIN 3, HUMAN AND RAT ENDOTHELIN-3 (HUMAN, MOUSE, RABBIT, RAT) ENDOTHELIN-3 (HUMAN) (PORCINE, RAT, RABBIT) ENDOTHELIN 3 HUMAN, RAT ENDOTHELIN-3 (HUMAN, RAT, PIG) ENDOTHELIN-3 (HUMAN, RAT, PORCINE, RABBIT) CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP HUMAN, RAT, PORCINE, RABBIT CTCFTYKDKECVYYCHLDIIW CTCFTYKDKECVYYCHLDIIW (DISULFIDE BRIDGE: 1-15 AND 3-11) H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH (DISULFIDE BRIDGE: 1-15 AND 3-11) ET-3, HUMAN ET-3, HUMAN AND RAT ET-3 (HUMAN, MOUSE, RABBIT, RAT) ET-3 (HUMAN, RAT) ET-3 (HUMAN, RAT, PIG) human,rat et-3 M.W. 2643.04 C121H168N26O33S4 Endothelin 3【canine】 Endothelin 3【rabbit】 Endothelin 3【rat】 CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR- TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP(DISULFIDE BRIDGE:CYS1-CYS15, CYS3-CYS11) CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP: CTCFTYKDKECVYYCHLDIIW DISULFIDE BRIDGES CYS1-CYS15, CYS3-CYS11 Endothelin-3 (huMan, Mouse, rabbit, rat) ET-3 (huMan, Mouse, rabbit, rat) Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridges Cys1-Cys15 and Cys3-Cys11) Endothelin 3 huMan, ratEndothelin Endothelin 3 (huMan)(9CI) Anti-EDN3 antibody produced in rabbit EDN3 HSCR4 ANTI-EDN3 (C-TERM) antibody produced in rabbit 19: PN: WO2007112069 SEQID: 10 claimed protein 33,34,49,50-Tetrathia-2,5,8,11,14,17,20,23,26,29,37,40,43,46-tetradecaazabicyclo[23.22.4]henpentacontane, cyclic peptide deriv. Endothelin 3 (mouse intestine) Human endothelin-3 Rat endothelin-3 ENDOTHELIN 3, HUMAN, RAT, 50 UG* Endothelin 3, human, rat, ≥97% (HPLC), powder Endothelin 3, Human and Rat - CAS 117399-93-6 - Calbiochem Endothelin 3 (Rat,Human) L-Tryptophan, L-cysteinyl-L-threonyl-L-cysteinyl-L-phenylalanyl-L-threonyl-L-tyrosyl-L-lysyl-L-α-aspartyl-L-lysyl-L-α-glutamyl-L-cysteinyl-L-valyl-L-tyrosyl-L-tyrosyl-L-cysteinyl-L-histidyl-L-leucyl-L-α-aspartyl-L-isoleucyl-L-isoleucyl-, cyclic (1→15),(3→11)-bis(disulfide) H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH USP/EP/BP Endothelin 3 human, rat (TFA) Human endothelin-3/Rat endothelin-3 CAS:117399-93-6 Endothelin 3, human, rat, mouse, rabbit (3S)-3-[[(2S)-2-[[(2S)-2-[[(1R,4S,7S,10S,13S,16S,19S,22S,25R,28S,31R,36R,39S,42S,45S)-31-amino-7,13-bis(4-aminobutyl)-22-benzyl-4-(2 -carboxyethyl)-10-(carboxymethyl)-19,28-bis[(1R)-1-hydroxyethyl]-16,39,42-tris[(4-hydroxyphenyl)methyl]-3,6,9,12,15,18,21, 117399-93-6 C121H168N26O33S4 Agonist BioChemical Amino Acids and Peptides Biochemicals and Reagents