Procarbazine hydrochloride
- CAS No.
- 366-70-1
- Chemical Name:
- Procarbazine hydrochloride
- Synonyms
- PROCARBAZINE HCL;matulane;ibz;Mutulane;nsc-77213;nci-c01810;NSC-77213 HCl;natulanhydrochloride;ibenzmethyzinhydrochloride;PROCARBAZINE HYDROCHLORIDE
- CBNumber:
- CB6678902
- Molecular Formula:
- C12H20ClN3O
- Molecular Weight:
- 257.76
- MDL Number:
- MFCD00072082
- MOL File:
- 366-70-1.mol
- MSDS File:
- SDS
| Melting point | 223°C |
|---|---|
| Density | 8.3 g/cm3 |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO: ≥18mg/mL |
| form | powder |
| color | white to tan |
| Water Solubility | >=10 g/100 mL at 21.5 ºC |
| Merck | 14,7758 |
| BCS Class | 3/1 |
| CAS DataBase Reference | 366-70-1(CAS DataBase Reference) |
| NCI Dictionary of Cancer Terms | Matulane; procarbazine hydrochloride |
| FDA UNII | XH0NPH5ZX8 |
| NCI Drug Dictionary | Matulane |
| Proposition 65 List | Procarbazine hydrochloride |
| IARC | 2A (Vol. 26, Sup 7) 1987 |
| EPA Substance Registry System | Procarbazine hydrochloride (366-70-1) |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H341-H350-H360 | |||||||||
| Precautionary statements | P201-P301+P312+P330-P308+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 45-61-22-68 | |||||||||
| Safety Statements | 53-36/37-45 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XS4725000 | |||||||||
| HS Code | 2928002500 | |||||||||
| Toxicity | LD50 orally in rats: 785 ±34 mg/kg (Goldenthal) | |||||||||
| NFPA 704 |
|
Procarbazine hydrochloride price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0036 | Procarbazine hydrochloride ≥98% (HPLC) | 366-70-1 | 10mg | $97.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1565009 | Procarbazine hydrochloride United States Pharmacopeia (USP) Reference Standard | 366-70-1 | 200mg | $393 | 2024-03-01 | Buy |
| TCI Chemical | P2550 | Procarbazine Hydrochloride >98.0%(HPLC)(T) | 366-70-1 | 100mg | $40 | 2024-03-01 | Buy |
| TCI Chemical | P2550 | Procarbazine Hydrochloride >98.0%(HPLC)(T) | 366-70-1 | 500mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 16133 | Procarbazine (hydrochloride) ≥98% | 366-70-1 | 50mg | $32 | 2024-03-01 | Buy |
Procarbazine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Crystalline Solid
Chemical Properties
Procarbazine is a white to pale yellow crystal- line powder with a slight odor.
Uses
Antineoplastic.
Uses
Antineoplastic;DNA replication inhibitor
Uses
Procarbazine hydrochloride USP is used to traet Hodgkin’s disease; non-Hodgkin’s lymphomas; lung cancer.
Definition
ChEBI: A hydrochloride obtained by combining procarbazine with one equivalent of hydrochloric acid. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaki g of DNA strands.
brand name
Matulane (Sigma-Tau).
General Description
Procarbazine is available in 50-mg tablets for oral administrationin the treatment of Hodgkin’s (part of MOPP) andnon-Hodgkin’s disease, brain cancer, and mycosis fungoides.The major mechanisms of resistance appear to beenhanced activity of DNA-repair enzymes including enhancedO-6-alkylguanine DNA transferase (AGAT),which removes the methyl group from the O-6 of guanine.The agent is rapidly and completely absorbed after oral administrationand extensively metabolized in the liver togive azo-procarbazine followed by further oxidation tomethyldiazine and the aldehyde. The parent drug andmetabolites cross the blood-brain barrier. Elimination occursin the urine mostly as metabolites with an eliminationhalf-life of 1 hour. Myelosuppression is dose limiting, generallypresenting as thrombocytopenia that may be followedby leucopenia. Glucose-6-phosphate dehydrogenasedeficient patients may develop hemolytic anemia duringprocarbazine therapy. Other adverse effects include nausea,vomiting, hypersensitivity, flulike symptoms, amenorrhea,and azoospermia. Central nervous symptom effectsmay be seen, including lethargy, confusion, neuropathies,and seizure.
General Description
White to pale yellow crystalline powder with a slight odor. Acid to litmus.
Air & Water Reactions
In the presence of moisture or in aqueous solution undergoes oxidation by atmospheric oxygen. Water soluble.
Reactivity Profile
Procarbazine hydrochloride is very sensitive to light. Stability is highest in aqueous acid and decreases with increasing pH. Degrades rapidly in alcoholic media and more slowly in aqueous media .
Fire Hazard
Flash point data for Procarbazine hydrochloride are not available; however, Procarbazine hydrochloride is probably combustible.
Biological Activity
Procarbazine is an antineoplastic alkylating agent widely used in cancer chemotherapy in combination with other compounds. It has multiple mechanisms of action. Procarbazine inhibits protein, RNA and DNA synthesis in addition to being an alkylating agent.', 'Procarbazine is metabolized to azoprocarbazine either by cytochrome P450 enzyme and monoamine oxidase in an NADPH (nicotinamide adenine diphosphate) dependent or independent manner. It is considered neurotoxic. Procarbazine is used in combination with therapy for treating Hodgkinμs disease.
Safety Profile
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by an unspecified route. Moderately toxic by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl. Used as a chemotherapeutic agent.
Potential Exposure
Procarbazine is available in capsule form. The primary use of this drug is as an antineoplastic agent in the treatment of advanced Hodgkin’s disease, and oat-cell carcinoma of the lung. The hydrochloride com- pound is used in treatment. The FDA approved use of pro- carbazine hydrochloride in 1969 and indicated that the drug should be used as an adjunct to standard therapy. Possible exposure occurs during manufacture of the drug and direct exposure during its subsequent administration to patients. Some of the metabolites of procarbazine hydrochloride are both carcinostatic and carcinogenic.
Veterinary Drugs and Treatments
In veterinary medicine, procarbazine is used as part of MOPP protocols (mechlorethamine, vincristine, procarbazine, prednisone) to treat lymphomas in dogs and cats. It may be of benefit in treating granulomatous meningoencephalitis (GME) in dogs.
Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
Waste Disposal
It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quanti- ties shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.
Procarbazine hydrochloride Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | abby@chuanghaibio.com | China | 8808 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3944 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12798 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5868 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29857 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
View Lastest Price from Procarbazine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-04 | Procarbazine hydrochloride
366-70-1
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2025-05-01 | Procarbazine hydrochloride
366-70-1
|
US $30.00-39.00 / mg | 98% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-04-28 | Procarbazine hydrochloride
366-70-1
|
US $39.00-84.00 / mg | 98% | 10g | TargetMol Chemicals Inc. |
-
- Procarbazine hydrochloride
366-70-1
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Procarbazine hydrochloride
366-70-1
- US $30.00-39.00 / mg
- 98%
- TargetMol Chemicals Inc.
-
- Procarbazine hydrochloride
366-70-1
- US $39.00-84.00 / mg
- 98%
- TargetMol Chemicals Inc.
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