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ChemicalBook >> CAS DataBase List >>Harpagoside

Harpagoside

CAS No.
19210-12-9
Chemical Name:
Harpagoside
Synonyms
side;Harpa;Harpagosid;Harpogoside;HARPAGOSIDE;HARPAGOSIDE(P);Harpagoside-RM;Harpagoside CRS;HARPAGOSIDE hplc;Einecs 242-881-6
CBNumber:
CB6240259
Molecular Formula:
C24H30O11
Molecular Weight:
494.49
MDL Number:
MFCD00017415
MOL File:
19210-12-9.mol
MSDS File:
SDS
Last updated:2025-04-17 18:22:24

Harpagoside Properties

Melting point 120°C (dec.)
Boiling point 720.7±60.0 °C(Predicted)
Density 1.52±0.1 g/cm3(Predicted)
storage temp. Inert atmosphere,2-8°C
solubility Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
pka 11.70±0.70(Predicted)
form Solid
color White to Light Yellow
optical activity [α]/D -50 to -30°
Stability Hygroscopic
InChIKey KVRQGMOSZKPBNS-FMHLWDFHSA-N
LogP -1.591 (est)
CAS DataBase Reference 19210-12-9(CAS DataBase Reference)
FDA UNII 8KGS1DC5ZU
UNSPSC Code 85151701
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  22
Safety Statements  22-45-24/25
RIDADR  3172
WGK Germany  3
HS Code  29389090

Harpagoside price More Price(49)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0000673 Harpagoside European Pharmacopoeia (EP) Reference Standard 19210-12-9 y0000673 $153 2024-03-01 Buy
Sigma-Aldrich 68527 Harpagoside analytical standard 19210-12-9 10mg $166 2024-03-01 Buy
Usbiological 293662 Harpagoside 19210-12-9 5mg $337 2021-12-16 Buy
Usbiological 451716 Harpagoside 19210-12-9 10mg $389 2021-12-16 Buy
Usbiological 300400 Harpagoside 19210-12-9 20mg $433 2021-12-16 Buy
Product number Packaging Price Buy
Y0000673 y0000673 $153 Buy
68527 10mg $166 Buy
293662 5mg $337 Buy
451716 10mg $389 Buy
300400 20mg $433 Buy

Harpagoside Chemical Properties,Uses,Production

Uses

Harpagoside is an iridoid glycoside along with with Harpagide (H105270), the potential to be strong anti-inflammatory agents providing the bulk of the observed effects from their plant origins.

Definition

ChEBI: Harpagoside is a terpene glycoside.

Biological Activity

Harpagoside is an orally available iridoid glycoside and an active component of Harpagophytum extract with cardioprotective effects. Harpagoside is shown to directly bind to and activate ACE2. Allosterically inhibits ACE2 binding to spike protein and reduces viral entry and lessen SARS-CoV-2 infection. Harpagoside was reported to suppress AP-1, IL-6, COX-1/2, c-FOS, NF-ĸB expression and upregulate BMP2 and Wnt signaling pathways.

in vivo

Harpagoside (5 mg/kg; 15 mg/kg; po; once daily for 60 days) has potential neuroprotective effects against Aβ intoxication in an Aβ1-40-induced rat Alzheimer's disease (AD) model[3].

IC 50

COX-1; COX-2

Harpagoside Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 294)Suppliers
Supplier Tel Email Country ProdList Advantage
Sinoway Industrial co., ltd. 		0592-5800732; +8613806035118 xie@china-sinoway.com China 987 58
Hebei Kingfiner Technology Development Co.Ltd 		+86-15532196582 +86-15373005021 lisa@kingfinertech.com China 3005 58
Shaanxi Haibo Biotechnology Co., Ltd 		+undefined18602966907 qinhe02@xaltbio.com China 997 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20235 58
BINBO BIOLOGICAL CO.,LTD 		+8618629063126 info@binbobiological.com China 452 58
Hebei Zhuanglai Chemical Trading Co Ltd 		+86-16264648883 +86-16264648883 niki@zlchemi.com China 7245 58
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3619 58
Chengdu Greenpure Biopharma CO.,Ltd 		18283602253; +8618283602253 jancyzheng@gcgreenpure.com China 953 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29858 58
Chengdu GLP biotechnology Co Ltd 		028-87075086 13350802083 scglp@glp-china.com CHINA 1824 58

View Lastest Price from Harpagoside manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Harpagoside pictures 2025-04-25 Harpagoside
19210-12-9
 US $150.00 / kg 1kg 99% 500kg Hebei Zhuanglai Chemical Trading Co Ltd
Harpagoside pictures 2025-04-25 Harpagoside
19210-12-9
 US $0.00-0.00 / Kg/Bag 1Kg/Bag 1.5%-20% UV 20 tons Sinoway Industrial co., ltd.
Harpagoside pictures 2025-04-25 Harpagoside
19210-12-9
 US $0.00 / KG 1KG 1-10% HPLC 1000KG Changsha Staherb Natural Ingredients Co., Ltd.
  • Harpagoside pictures
  • Harpagoside
    19210-12-9
  • US $150.00 / kg
  • 99%
  • Hebei Zhuanglai Chemical Trading Co Ltd
  • Harpagoside pictures
  • Harpagoside
    19210-12-9
  • US $0.00-0.00 / Kg/Bag
  • 1.5%-20% UV
  • Sinoway Industrial co., ltd.
  • Harpagoside pictures
  • Harpagoside
    19210-12-9
  • US $0.00 / KG
  • 1-10% HPLC
  • Changsha Staherb Natural Ingredients Co., Ltd.
HARPAGOSIDE Harpagosid [1S-[1alpha,4aalpha,5alpha,7alpha(E),7aalpha]]-1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[(allyl-1-oxo-3-phenyl)oxy]cyclopenta[c]pyran-1-yl-beta-D-glucopyranoside [(1S,4aS,5R,7S,7aS)-4a,5-Dihydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,5,6,7a-tetrahydrocyclopenta[c]pyran-7-yl] (E)-3-phenylprop-2-enoate HARPAGOSIDE WITH HPLC 7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]oxy]cyclopenta[c]pyran-1-yl β-D-Glucopyranoside, (1S,4aS,5R,7S,7aS)-1,4a,5,6 8-O-E CINNAMOYL HARPAGIDE 8'-CINNAMOYLHARPAGIDE Harpogoside HARPAGOSIDE hplc [(1S)-1,4a,5,6,7,7aα-Hexahydro-4aα,5α-dihydroxy-7-methyl-7α-[[(E)-1-oxo-3-phenyl-2-propenyl]oxy]cyclopenta[c]pyran-1α-yl]β-D-glucopyranoside (1S-(1alpha,4Aalpha,5alpha,7alpha(E),7aalpha))-1,4A,5,6,7,7A-hexahydro-4A,5-dihydroxy-7-methyl-7-((allyl-1-oxo-3-phenyl)oxy)cyclopenta(C)pyran-1-yl-beta-D-glucopyranoside Einecs 242-881-6 HARPAGOSIDE(P) Harpagoside ,98% Devil s Claw,grapple plant,wood spider Harpa side Harpagoside, 98%, from Harpagophytum procumbens D.C. Harpagoside CRS β-D-Glucopyranoside, (1S,4aS,5R,7S,7aS)-1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]oxy]cyclopenta[c]pyran-1-yl (1S,4aS,5R,7S,7aS)-4a,5-Dihydroxy-7-methyl-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-7-yl cinnamate HARPAGOSIDE(RG) 100mg HARPAGOSIDE(RG) 25mg Harpagoside-RM 19210-12-9 C24H30O11 4945 chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract reference substance Nitric Oxide Iridoids HA -HTChemical Class Herbal Drugs Natural Compounds Alphabetic H 19210-12-9