8-EPI PGF2ALPHA-D4
- CAS No.
- 211105-40-7
- Chemical Name:
- 8-EPI PGF2ALPHA-D4
- Synonyms
- IPF2ALPHA-IIID4;8-ISOPROSTANE-D4;8-EPI PGF2ALPHA-D4;8-iso Prostaglandin F2α-d4;PXGPLTODNUVGFL-FLRLWOSLSA-N;8-ISO PROSTAGLANDIN F2ALPHA-D4;9ALPHA, 11ALPHA, 15S-TRIHYDROXY-(8BETA)-PROSTA-5Z, 13E-DIEN-1-OIC-3,3,4,4-D4 ACID
- CBNumber:
- CB6149006
- Molecular Formula:
- C20H30D4O5
- Molecular Weight:
- 358.51
- MDL Number:
- MFCD00797664
- MOL File:
- 211105-40-7.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319-H336 | |||||||||
| Precautionary statements | P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501 | |||||||||
| NFPA 704 |
|
8-EPI PGF2ALPHA-D4 price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 316350 | 8-iso Prostaglandin F2α-d4 ≥99% deuterated forms (d1-d4) | 211105-40-7 | 25μg | $165 | 2024-03-01 | Buy |
| Cayman Chemical | 316350 | 8-iso Prostaglandin F2α-d4 ≥99% deuterated forms (d1-d4) | 211105-40-7 | 50μg | $311 | 2024-03-01 | Buy |
| Cayman Chemical | 316350 | 8-iso Prostaglandin F2α-d4 ≥99% deuterated forms (d1-d4) | 211105-40-7 | 100μg | $587 | 2024-03-01 | Buy |
| Cayman Chemical | 316350 | 8-iso Prostaglandin F2α-d4 ≥99% deuterated forms (d1-d4) | 211105-40-7 | 500μg | $2144 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 404 | 8-isoProstaglandin-F2-α(3,3,4,4-d4) | 211105-40-7 | 100ug | $890 | 2021-12-16 | Buy |
8-EPI PGF2ALPHA-D4 Chemical Properties,Uses,Production
Uses
8-Iso-PGF2a-d4 (8-iso Prostaglandin F2α-d4) is an active compound. 8-Iso-PGF2a-d4 can be used the internal standard[1].
Biological Activity
8-iso PGF2α-d4 contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 8-iso PGF2α by GC- or LC-mass spectrometry. 8-iso Prostaglandin F2α (8-iso PGF2α) is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids.1,2,3 It circulates in human plasma in two distinct forms - esterified in LDL phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2α level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2α levels are about 180-200 pg/mg of creatinine.1,2 8-iso PGF2α is a weak TP receptor agonist in vascular smooth muscle.4 Conversely, 8-iso PGF2α inhibits platelet aggregation induced by U-46619 (10-6 M) and I-BOP (3 x 10-7 M) with IC50 values of 1.6 x 10-6 M and 1.8 x 10-6 M, respectively.3
References
1.Morrow, J.D., Hill, K.E., Burk, R.F., et al.A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanismProc. Natl. Acad. Sci. U.S.A.87(23)9383-9387(1990) 2.Morrow, J.D., Harris, T.M., and Roberts, L.J., IINoncyclooxygenase oxidative formation of a series of novel prostaglandins: Analytical ramifications for measurement of eicosanoidsAnal. Biochem.184(1)1-10(1990) 3.Morrow, J.D., Minton, T.A., and Roberts, L.J., IIThe F2-isoprostane, 8-epi-prostaglandin F2α, a potent agonist of the vascular thromboxane/endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonistProstaglandins44(2)155-163(1992) 4.Kiriyama, M., Ushikubi, F., Kobayashi, T., et al.Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cellsBr. J. Pharmacol.122(2)217-224(1997)
8-EPI PGF2ALPHA-D4 Preparation Products And Raw materials
Raw materials
Preparation Products
8-EPI PGF2ALPHA-D4 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Hangzhou Synstar pharmaceutical Technology CO.,Ltd | 0571-85361029 | synstar518@163.com | China | 1990 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 13774214275 | zhouzz@univ-bio.com | China | 25002 | 58 |
| Hubei wei shi reagent group ltd., company | 027-59102966 18717199209 | 2853877583@qq.com | China | 2990 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 028-81700200 13308200041 | 2851167782@qq.com | China | 11183 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 27736 | 58 |
| Santa Cruz Biotechnology Inc | 60936350 | scbt@scbt.com | China | 222068 | 58 |