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ChemicalBook >> CAS DataBase List >>McMMAE

McMMAE

CAS No.
863971-24-8
Chemical Name:
McMMAE
Synonyms
McMMAE;Mc-MMAE;Mc MMAE;Mc-MMAE, 10 mM in DMSO;Maleimidocaproyl-monomethylauristatin E;37: PN: WO2007140371 PAGE: 273 claimed sequence;Mc-MMAE,Inhibitor,Drug-Linker Conjugates for ADC,McMMAE,Microtubule/Tubulin,Mc MMAE,inhibit;L-Valinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-;6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-[(1S)-1-{[(1S)-1-{[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-2-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]carbamoyl}-1-methoxy-2-methylethyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl](methyl)carbamoyl}-2-methylpropyl]carbamoyl}-2-methylpropyl]-N-methylhexanamide;6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-(((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-N-methylhexanamide
CBNumber:
CB52668694
Molecular Formula:
C49H78N6O10
Molecular Weight:
911.18
MDL Number:
MFCD28167757
MOL File:
863971-24-8.mol
MSDS File:
SDS
Last updated:2025-04-17 18:22:24

McMMAE Properties

Boiling point 1025.2±65.0 °C(Predicted)
Density 1.144±0.06 g/cm3(Predicted)
storage temp. Store at -20°C,unstable in solution, ready to use.
solubility DMSO: ≥ 51 mg/mL (55.97 mM)
pka 13.63±0.46(Predicted)
form Powder
color White to light yellow

McMMAE price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-2739 Mc-MMAE 96.47% 863971-24-8 1mg $660 2021-12-16 Buy
ChemScene CS-2739 Mc-MMAE 96.47% 863971-24-8 5mg $1176 2021-12-16 Buy
ChemScene CS-2739 Mc-MMAE 96.47% 863971-24-8 10mg $1800 2021-12-16 Buy
Crysdot CD35000016 Mc-MMAE 98+% 863971-24-8 10mg $977 2021-12-16 Buy
Crysdot CD35000016 Mc-MMAE 98+% 863971-24-8 5mg $638 2021-12-16 Buy
Product number Packaging Price Buy
CS-2739 1mg $660 Buy
CS-2739 5mg $1176 Buy
CS-2739 10mg $1800 Buy
CD35000016 10mg $977 Buy
CD35000016 5mg $638 Buy

McMMAE Chemical Properties,Uses,Production

Uses

Mc-MMAE is a protective group (maleimidocaproyl)-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Mc-MMAE is a agent-linker conjugate for ADC.

IC 50

Auristatin

References

[1] Sanderson RJ, et al. In vivo drug-linker stability of an anti-CD30 dipeptide-linked auristatin immunoconjugate. Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):843-52. PMID:15701875

55750-53-3
474645-27-7
863971-24-8
Synthesis of McMMAE from 6-Maleimidocaproic acid and MonoMethyl auristatin E

McMMAE Preparation Products And Raw materials

Global( 78)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou Benoy Chemical Co., Ltd
+8617342059697 sales@benoychem.com China 315 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Shandong chuangyingchemical Co., Ltd. 		18853181302 sale@chuangyingchem.com CHINA 5906 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Jurong Coupling Biotechnology Co., Ltd. 		13656108824 coupling278191416@hotmail.com CHINA 184 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29808 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81139210 +86-18192627656 1059@dideu.com China 3030 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32265 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Hangzhou Huarong Pharm Co., Ltd. 		571-86758373 +8613588754946 sales@huarongpharm.com CHINA 3148 58

View Lastest Price from McMMAE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Mc-MMAE pictures 2024-11-19 Mc-MMAE
863971-24-8
 US $163.00-562.00 / mg ≥98% 10g TargetMol Chemicals Inc.
MC-MMAE pictures 2021-09-16 MC-MMAE
863971-24-8
 US $0.00-0.00 / g 100mg 99% 500KG Hangzhou Huarong Pharm Co., Ltd.
McMMAE pictures 2020-03-16 McMMAE
863971-24-8
 US $1.00-0.00 / KG 1KG 99% 10000KG Shaanxi Dideu Medichem Co. Ltd
  • Mc-MMAE pictures
  • Mc-MMAE
    863971-24-8
  • US $163.00-562.00 / mg
  • ≥98%
  • TargetMol Chemicals Inc.
  • MC-MMAE pictures
  • MC-MMAE
    863971-24-8
  • US $0.00-0.00 / g
  • 99%
  • Hangzhou Huarong Pharm Co., Ltd.
  • McMMAE pictures
  • McMMAE
    863971-24-8
  • US $1.00-0.00 / KG
  • 99%
  • Shaanxi Dideu Medichem Co. Ltd
Mc MMAE McMMAE Mc-MMAE 37: PN: WO2007140371 PAGE: 273 claimed sequence Maleimidocaproyl-monomethylauristatin E L-Valinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl- Mc-MMAE,Inhibitor,Drug-Linker Conjugates for ADC,McMMAE,Microtubule/Tubulin,Mc MMAE,inhibit 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-(((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-N-methylhexanamide 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-[(1S)-1-{[(1S)-1-{[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-2-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]carbamoyl}-1-methoxy-2-methylethyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl](methyl)carbamoyl}-2-methylpropyl]carbamoyl}-2-methylpropyl]-N-methylhexanamide Mc-MMAE, 10 mM in DMSO 863971-24-8 C49H78N6O10 ADCs ADC LINKER